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Pregabalin and dexmedetomidine
Pregabalin and dexmedetomidine together enhance pain relief and sedation by increasing inhibitory neurotransmission and activating alpha-2 adrenergic receptors.
Pregabalin and dexmedetomidine together enhance pain relief and sedation by increasing inhibitory neurotransmission and activating alpha-2 adrenergic receptors. Used for Perioperative analgesia and sedation, Postoperative pain management.
At a glance
| Generic name | Pregabalin and dexmedetomidine |
|---|---|
| Also known as | study drugs |
| Sponsor | Wonkwang University Hospital |
| Drug class | Combination analgesic/sedative (gabapentinoid + alpha-2 agonist) |
| Target | Alpha-2-delta calcium channel subunit (pregabalin); alpha-2 adrenergic receptor (dexmedetomidine) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia, Pain Management, Perioperative Medicine |
| Phase | FDA-approved |
Mechanism of action
Pregabalin is a gabapentinoid that binds to the alpha-2-delta subunit of voltage-gated calcium channels, reducing excitatory neurotransmitter release and providing analgesic and anxiolytic effects. Dexmedetomidine is a selective alpha-2 adrenergic agonist that produces sedation, analgesia, and anxiolysis through central nervous system effects. The combination is used perioperatively to enhance anesthesia and analgesia while reducing opioid requirements.
Approved indications
- Perioperative analgesia and sedation
- Postoperative pain management
Common side effects
- Dizziness
- Somnolence
- Dry mouth
- Hypotension
- Bradycardia
Key clinical trials
- The Efficacy and Safety of Pregabalin Combined With Dexmedetomidine in Patients With Fibromyalgia (NA)
- Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy (NA)
- Pregabalin Versus Dexmedetomidine for Delirium Treatment After Coronary Artery Bypass Grafting (PHASE4)
- Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair (PHASE4)
- Pregabalin Versus Dexmedetomidine for Delirium Prevention After Cardiac Surgery (PHASE4)
- Effect of Perioperative Oral Pregabalin in Total Knee Replacement (PHASE4)
- Multimodal Versus Opioid aNalgesia in carDiAc Surgery (PHASE4)
- Multimodal Opioid-free Anesthesia Versus Opioid-based Anesthesia for Patients Undergoing Cardiac Valve Surgeries: RCT (EARLY_PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Pregabalin and dexmedetomidine CI brief — competitive landscape report
- Pregabalin and dexmedetomidine updates RSS · CI watch RSS
- Wonkwang University Hospital portfolio CI