{"id":"pregabalin-and-dexmedetomidine","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Somnolence"},{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Pregabalin is a gabapentinoid that binds to the alpha-2-delta subunit of voltage-gated calcium channels, reducing excitatory neurotransmitter release and providing analgesic and anxiolytic effects. Dexmedetomidine is a selective alpha-2 adrenergic agonist that produces sedation, analgesia, and anxiolysis through central nervous system effects. The combination is used perioperatively to enhance anesthesia and analgesia while reducing opioid requirements.","oneSentence":"Pregabalin and dexmedetomidine together enhance pain relief and sedation by increasing inhibitory neurotransmission and activating alpha-2 adrenergic receptors.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:02:29.151Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Perioperative analgesia and sedation"},{"name":"Postoperative pain management"}]},"trialDetails":[{"nctId":"NCT07230197","phase":"NA","title":"The Efficacy and Safety of Pregabalin Combined With Dexmedetomidine in Patients With Fibromyalgia","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-09-30","conditions":"Fibromyalgia, Pregabalin, Dexmedetomidine","enrollment":400},{"nctId":"NCT07084753","phase":"NA","title":"Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy","status":"NOT_YET_RECRUITING","sponsor":"IVO JURISIC","startDate":"2025-07-30","conditions":"Obese Patients, Bariatric Surgical Pain, Bariatric Surgery (Sleeve Gastrectomy )","enrollment":36},{"nctId":"NCT05640453","phase":"PHASE4","title":"Pregabalin Versus Dexmedetomidine for Delirium Treatment After Coronary Artery Bypass Grafting","status":"RECRUITING","sponsor":"Tanta University","startDate":"2022-12-15","conditions":"Pregabalin, Delirium Treatment, Coronary Artery Bypass Grafting","enrollment":70},{"nctId":"NCT04894864","phase":"PHASE4","title":"Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair","status":"RECRUITING","sponsor":"University of Crete","startDate":"2020-10-08","conditions":"Elective Surgical Procedures, Postoperative Pain, Anesthesia","enrollment":40},{"nctId":"NCT05640479","phase":"PHASE4","title":"Pregabalin Versus Dexmedetomidine for Delirium Prevention After Cardiac Surgery","status":"COMPLETED","sponsor":"Tanta University","startDate":"2022-12-15","conditions":"Pregabalin, Dexmedetomidine, Delirium","enrollment":60},{"nctId":"NCT06187922","phase":"PHASE4","title":"Effect of Perioperative Oral Pregabalin in Total Knee Replacement","status":"UNKNOWN","sponsor":"Bahrain Defence Force Hospital","startDate":"2023-09-01","conditions":"Postoperative Pain","enrollment":120},{"nctId":"NCT04987372","phase":"PHASE4","title":"Multimodal Versus Opioid aNalgesia in carDiAc Surgery","status":"COMPLETED","sponsor":"University Hospital, Ghent","startDate":"2019-01-21","conditions":"Postoperative Pain, Postoperative Delirium","enrollment":100},{"nctId":"NCT04648540","phase":"EARLY_PHASE1","title":"Multimodal Opioid-free Anesthesia Versus Opioid-based Anesthesia for Patients Undergoing Cardiac Valve Surgeries: RCT","status":"COMPLETED","sponsor":"Cairo University","startDate":"2020-12-01","conditions":"Anesthesia","enrollment":60},{"nctId":"NCT05829148","phase":"EARLY_PHASE1","title":"The Effect of Dexmedetomidine, Melatonin and Pregabalin","status":"UNKNOWN","sponsor":"Egymedicalpedia","startDate":"2023-05-01","conditions":"Endoscopic Sinus Surgery","enrollment":120},{"nctId":"NCT05172739","phase":"PHASE4","title":"Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC","status":"RECRUITING","sponsor":"University of Crete","startDate":"2021-10-01","conditions":"Systemic Inflammatory Response Syndrome, Postoperative Pain, Acute, Postoperative Pain, Chronic","enrollment":70},{"nctId":"NCT03735368","phase":"PHASE2","title":"Dexmedetomidine and Pregabalin for Conscious Sedation During Cataract Surgery","status":"COMPLETED","sponsor":"Abd-Elazeem Abd-Elhameed Elbakry","startDate":"2018-12-10","conditions":"Conscious Sedation","enrollment":60},{"nctId":"NCT03512574","phase":"PHASE4","title":"Combination Effects of Pregabalin and Dexmedetomidine on Postoperative Pain","status":"COMPLETED","sponsor":"Wonkwang University Hospital","startDate":"2018-01-02","conditions":"Pain, Postoperative","enrollment":150}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["study drugs"],"phase":"marketed","status":"active","brandName":"Pregabalin and dexmedetomidine","genericName":"Pregabalin and dexmedetomidine","companyName":"Wonkwang University Hospital","companyId":"wonkwang-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pregabalin and dexmedetomidine together enhance pain relief and sedation by increasing inhibitory neurotransmission and activating alpha-2 adrenergic receptors. Used for Perioperative analgesia and sedation, Postoperative pain management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}