Last reviewed 2026-04-23 · How we verify

Tramadol/Diclofenac 25/25

Tramadol/Diclofenac 25/25 is a Opioid analgesic/NSAID Small molecule drug developed by Grünenthal GmbH. It is currently in Phase 3 development for Moderate to severe pain, Osteoarthritis. Also known as: Adorlan (Registered Trademark).

Tramadol is a centrally acting opioid analgesic, while diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits prostaglandin synthesis.

Tramadol is a centrally acting opioid analgesic, while diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits prostaglandin synthesis. Used for Moderate to severe pain, Osteoarthritis.

At a glance

Mechanism of action

Tramadol works by binding to opioid receptors in the brain and spinal cord, reducing the perception of pain. Diclofenac, on the other hand, blocks the production of prostaglandins, which are hormone-like substances that cause pain and inflammation. By combining these two mechanisms, tramadol/diclofenac provides effective pain relief for a range of conditions.

Approved indications

• Moderate to severe pain
• Osteoarthritis

Common side effects

• Nausea
• Dizziness
• Headache
• Abdominal pain
• Diarrhea

Key clinical trials

• ACL-R Opioid Sparing Study (PHASE3)
• PROUD Study - Preventing Opioid Use Disorders (PHASE4)
• Ultrasound-guided Two Different Type Blocks for Pain Relief in Totalabdominal Hysterectomy (NA)
• Tramadol/Diclofenac Fixed-dose Combination Phase III Trial in Acute Pain After Third Molar Extraction (PHASE3)
• Pharmacokinetic Non-interaction Study With a Fixed-dose Combination Tablet With Tramadol and Diclofenac (PHASE1)

Primary sources

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Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Tramadol/Diclofenac 25/25 CI brief — competitive landscape report
• Tramadol/Diclofenac 25/25 updates RSS · CI watch RSS
• Grünenthal GmbH portfolio CI

Frequently asked questions about Tramadol/Diclofenac 25/25

Related

• Drug class: All Opioid analgesic/NSAID drugs
• Target: All drugs targeting Opioid receptors/COX enzymes
• Manufacturer: Grünenthal GmbH — full pipeline
• Therapeutic area: All drugs in Pain management
• Indication: Drugs for Moderate to severe pain
• Indication: Drugs for Osteoarthritis
• Also known as: Adorlan (Registered Trademark)