{"id":"tramadol-diclofenac-25-25","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Dizziness"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Abdominal pain"},{"rate":"5-10%","effect":"Diarrhea"}]},"_chembl":{"chemblId":"CHEMBL1237065","moleculeType":"Small molecule","molecularWeight":"299.84"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Tramadol works by binding to opioid receptors in the brain and spinal cord, reducing the perception of pain. Diclofenac, on the other hand, blocks the production of prostaglandins, which are hormone-like substances that cause pain and inflammation. By combining these two mechanisms, tramadol/diclofenac provides effective pain relief for a range of conditions.","oneSentence":"Tramadol is a centrally acting opioid analgesic, while diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits prostaglandin synthesis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:39:39.197Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate to severe pain"},{"name":"Osteoarthritis"}]},"trialDetails":[{"nctId":"NCT06561035","phase":"PHASE3","title":"ACL-R Opioid Sparing Study","status":"ENROLLING_BY_INVITATION","sponsor":"Campbell Clinic","startDate":"2024-09-01","conditions":"Anterior Cruciate Ligament Injuries","enrollment":56},{"nctId":"NCT04766996","phase":"PHASE4","title":"PROUD Study - Preventing Opioid Use Disorders","status":"TERMINATED","sponsor":"Emory University","startDate":"2021-05-17","conditions":"Anesthesia, Opioid Use","enrollment":57},{"nctId":"NCT04297046","phase":"NA","title":"Ultrasound-guided Two Different Type Blocks for Pain Relief in Totalabdominal Hysterectomy","status":"COMPLETED","sponsor":"Bursa Yuksek Ihtisas Training and Research Hospital","startDate":"2017-04-01","conditions":"Ultrasonography","enrollment":70},{"nctId":"NCT03714672","phase":"PHASE3","title":"Tramadol/Diclofenac Fixed-dose Combination Phase III Trial in Acute Pain After Third Molar Extraction","status":"COMPLETED","sponsor":"Grünenthal GmbH","startDate":"2017-08-26","conditions":"Acute Pain","enrollment":1151},{"nctId":"NCT03766984","phase":"PHASE1","title":"Pharmacokinetic Non-interaction Study With a Fixed-dose Combination Tablet With Tramadol and Diclofenac","status":"COMPLETED","sponsor":"Grünenthal GmbH","startDate":"2015-06-07","conditions":"Pharmacokinetics","enrollment":36}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Adorlan (Registered Trademark)"],"phase":"phase_3","status":"active","brandName":"Tramadol/Diclofenac 25/25","genericName":"Tramadol/Diclofenac 25/25","companyName":"Grünenthal GmbH","companyId":"gr-nenthal-gmbh","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tramadol is a centrally acting opioid analgesic, while diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits prostaglandin synthesis. Used for Moderate to severe pain, Osteoarthritis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}