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Ticagrelor followed with Morphine
Ticagrelor followed with Morphine is a P2Y12 inhibitor (ticagrelor) + opioid analgesic (morphine) Small molecule drug developed by Collegium Medicum w Bydgoszczy. It is currently FDA-approved for Acute coronary syndrome (STEMI/NSTEMI) with pain management. Also known as: Brilique + Morphine.
Ticagrelor inhibits platelet aggregation via P2Y12 receptor antagonism, while morphine provides opioid analgesia; together they are used in acute coronary syndrome to prevent thrombotic events and manage pain.
Ticagrelor inhibits platelet aggregation via P2Y12 receptor antagonism, while morphine provides opioid analgesia; together they are used in acute coronary syndrome to prevent thrombotic events and manage pain. Used for Acute coronary syndrome (STEMI/NSTEMI) with pain management.
At a glance
| Generic name | Ticagrelor followed with Morphine |
|---|---|
| Also known as | Brilique + Morphine |
| Sponsor | Collegium Medicum w Bydgoszczy |
| Drug class | P2Y12 inhibitor (ticagrelor) + opioid analgesic (morphine) |
| Target | P2Y12 receptor (ticagrelor); mu-opioid receptor (morphine) |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Ticagrelor is a direct P2Y12 receptor antagonist that reversibly blocks ADP-induced platelet aggregation, reducing thrombotic complications in acute coronary syndromes. Morphine acts as a mu-opioid receptor agonist to provide analgesia and anxiolysis. This combination addresses both the antiplatelet and analgesic needs in acute myocardial infarction management.
Approved indications
- Acute coronary syndrome (STEMI/NSTEMI) with pain management
Common side effects
- Bradycardia
- Dyspnea
- Bleeding
- Respiratory depression (morphine)
- Nausea
Key clinical trials
- Influence of METHoxyflurane on ANtiplatelet Effect of Ticagrelor in Patients With Unstable Angina Pectoris (PHASE4)
- Platelet Inhibition After Pre-hospital Ticagrelor Using Fentanyl Compared to Morphine in Patients With ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention (NA)
- Influence of Naloxone on Ticagrelor Pharmacokinetics and Pharmacodynamics in Patients With Unstable Angina Pectoris on Concomitant Treatment With Morphine (PHASE4)
- Influence of Metoclopramide on Ticagrelor Pharmacokinetics and Pharmacodynamics in Patients With Unstable Angina Pectoris on Concomitant Treatment With Morphine (PHASE4)
- Influence of Morphine on Pharmacokinetics and Pharmacodynamics of Ticagrelor in Patients With Acute Myocardial Infarction (PHASE4)
- Effect of Methylnaltrexone on the PK/PD Profiles of Ticagrelor in Patients Treated With Morphine (PHASE4)
- Ticagrelor and Intracoronary Morphine in Patients Undergoing Primary Percutaneous Coronary Intervention (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ticagrelor followed with Morphine CI brief — competitive landscape report
- Ticagrelor followed with Morphine updates RSS · CI watch RSS
- Collegium Medicum w Bydgoszczy portfolio CI
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Related
- Drug class: All P2Y12 inhibitor (ticagrelor) + opioid analgesic (morphine) drugs
- Target: All drugs targeting P2Y12 receptor (ticagrelor); mu-opioid receptor (morphine)
- Manufacturer: Collegium Medicum w Bydgoszczy — full pipeline
- Therapeutic area: All drugs in Cardiovascular
- Indication: Drugs for Acute coronary syndrome (STEMI/NSTEMI) with pain management
- Also known as: Brilique + Morphine
- Compare: Ticagrelor followed with Morphine vs similar drugs
- Pricing: Ticagrelor followed with Morphine cost, discount & access