Comparison of Analgesia With Fentanyl and Morphine on Platelet Inhibition After Pre-hospital Ticagrelor Administration in Patients With ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention (PERSEUS)

NCT02531165 NA COMPLETED

Prospective, randomized, open-label, single-center, investigator-initiated trial, including patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) within 12 hours of the symptom's onset. The study aims to compare platelet inhibition (pharmacodynamics and pharmacokinetics) of pre-hospital Ticagrelor in patients with STEMI according to two different analgesia protocols using Fentanyl or Morphine.

Details

Lead sponsor	Centre Hospitalier Universitaire Vaudois
Phase	NA
Status	COMPLETED
Enrolment	38
Start date	2015-09
Completion	2018-02-06

Conditions

• Acute Myocardial Infarction

Interventions

• Fentanyl
• Morphine
• Ticagrelor
• Aspirin
• Unfractioned Heparin
• Primary PCI

Primary outcomes

• Residual platelet reactivity (PR) by Platelet Reactivity Units (PRU) — 2 hours after loading dose of Ticagrelor

Countries

Switzerland