{"id":"ticagrelor-followed-with-morphine","safety":{"commonSideEffects":[{"rate":"5-10","effect":"Bradycardia"},{"rate":"5-10","effect":"Dyspnea"},{"rate":"5-15","effect":"Bleeding"},{"rate":"variable","effect":"Respiratory depression (morphine)"},{"rate":"10-20","effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ticagrelor is a direct P2Y12 receptor antagonist that reversibly blocks ADP-induced platelet aggregation, reducing thrombotic complications in acute coronary syndromes. Morphine acts as a mu-opioid receptor agonist to provide analgesia and anxiolysis. This combination addresses both the antiplatelet and analgesic needs in acute myocardial infarction management.","oneSentence":"Ticagrelor inhibits platelet aggregation via P2Y12 receptor antagonism, while morphine provides opioid analgesia; together they are used in acute coronary syndrome to prevent thrombotic events and manage pain.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:12:35.886Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute coronary syndrome (STEMI/NSTEMI) with pain management"}]},"trialDetails":[{"nctId":"NCT04442919","phase":"PHASE4","title":"Influence of METHoxyflurane on ANtiplatelet Effect of Ticagrelor in Patients With Unstable Angina Pectoris","status":"COMPLETED","sponsor":"Collegium Medicum w Bydgoszczy","startDate":"2020-06-01","conditions":"Unstable Angina","enrollment":72},{"nctId":"NCT02531165","phase":"NA","title":"Platelet Inhibition After Pre-hospital Ticagrelor Using Fentanyl Compared to Morphine in Patients With ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire Vaudois","startDate":"2015-09","conditions":"Acute Myocardial Infarction","enrollment":38},{"nctId":"NCT02939248","phase":"PHASE4","title":"Influence of Naloxone on Ticagrelor Pharmacokinetics and Pharmacodynamics in Patients With Unstable Angina Pectoris on Concomitant Treatment With Morphine","status":"COMPLETED","sponsor":"Collegium Medicum w Bydgoszczy","startDate":"2016-10","conditions":"Unstable Angina Pectoris","enrollment":30},{"nctId":"NCT02939235","phase":"PHASE4","title":"Influence of Metoclopramide on Ticagrelor Pharmacokinetics and Pharmacodynamics in Patients With Unstable Angina Pectoris on Concomitant Treatment With Morphine","status":"COMPLETED","sponsor":"Collegium Medicum w Bydgoszczy","startDate":"2016-07","conditions":"Unstable Angina Pectoris","enrollment":32},{"nctId":"NCT02217878","phase":"PHASE4","title":"Influence of Morphine on Pharmacokinetics and Pharmacodynamics of Ticagrelor in Patients With Acute Myocardial Infarction","status":"COMPLETED","sponsor":"Collegium Medicum w Bydgoszczy","startDate":"2014-08","conditions":"ST-segment Elevation Myocardial Infarction, Non-ST-segment Elevation Myocardial Infarction, VA Drug Interactions","enrollment":74},{"nctId":"NCT02403830","phase":"PHASE4","title":"Effect of Methylnaltrexone on the PK/PD Profiles of Ticagrelor in Patients Treated With Morphine","status":"COMPLETED","sponsor":"University of Florida","startDate":"2015-08","conditions":"Coronary Artery Disease","enrollment":30},{"nctId":"NCT01738100","phase":"PHASE2","title":"Ticagrelor and Intracoronary Morphine in Patients Undergoing Primary Percutaneous Coronary Intervention","status":"UNKNOWN","sponsor":"Hyeon-Cheol Gwon","startDate":"2012-09","conditions":"ST-Segment Elevation Myocardial Infarction","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Brilique + Morphine"],"phase":"marketed","status":"active","brandName":"Ticagrelor followed with Morphine","genericName":"Ticagrelor followed with Morphine","companyName":"Collegium Medicum w Bydgoszczy","companyId":"collegium-medicum-w-bydgoszczy","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ticagrelor inhibits platelet aggregation via P2Y12 receptor antagonism, while morphine provides opioid analgesia; together they are used in acute coronary syndrome to prevent thrombotic events and manage pain. Used for Acute coronary syndrome (STEMI/NSTEMI) with pain management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}