Who is sponsoring IMPRESSION?

IMPRESSION is sponsored by Collegium Medicum w Bydgoszczy.

What condition does IMPRESSION study?

IMPRESSION studies ST-segment Elevation Myocardial Infarction, Non-ST-segment Elevation Myocardial Infarction, VA Drug Interactions.

What drugs are being tested in IMPRESSION?

Interventions: Morphine, Placebo, Ticagrelor.

What is the status of IMPRESSION?

IMPRESSION is currently COMPLETED.

Last reviewed 2017-08-12 · How we verify

A Randomized, Double-blind Study Evaluating the Influence of Morphine on Pharmacokinetics and Pharmacodynamics of Ticagrelor and Its Active Metabolite (AR-C124910XX) in Patients With ST-segment Elevation Myocardial Infarction and Non-ST-segment Elevation Myocardial Infarction. (IMPRESSION)

NCT02217878 Phase 4 COMPLETED Results posted

The purpose of the IMPRESSION study is to determine whether intravenous administration of morphine prior to ticagrelor administration in ST-segment elevation myocardial infarction (STEMI) patients and in non-ST-segment elevation myocardial infarction (NSTEMI) patients alters the plasma concentrations of ticagrelor and its active metabolite and whether it is associated with any negative impact on the antiplatelet effect of ticagrelor.

Details

Lead sponsor	Collegium Medicum w Bydgoszczy
Phase	Phase 4
Status	COMPLETED
Enrolment	74
Start date	2014-08
Completion	2015-06

Conditions

ST-segment Elevation Myocardial Infarction
Non-ST-segment Elevation Myocardial Infarction
VA Drug Interactions

Interventions

Morphine
Placebo
Ticagrelor

Primary outcomes

Area Under the Plasma Concentration-time Curve for Ticagrelor (AUC 0-12h) — prior to the initial dose and 30min, 1h, 2h, 3h, 4h, 6h, 12h post dose
Exposure to ticagrelor during the first 12 hours after ticagrelor loading dose

Countries

Poland