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sulfadoxine pyrimethamine plus piperaquine
sulfadoxine pyrimethamine plus piperaquine is a Antifolate antimalarial combination with quinoline antimalarial Small molecule drug developed by London School of Hygiene and Tropical Medicine. It is currently in Phase 3 development for Malaria treatment and prevention (Plasmodium falciparum and Plasmodium vivax). Also known as: sulfadoxine pyrimethamine, piperaquine phosphate.
This combination drug inhibits parasite folate synthesis (sulfadoxine-pyrimethamine) and disrupts parasite mitochondrial function (piperaquine) to treat malaria.
This combination drug inhibits parasite folate synthesis (sulfadoxine-pyrimethamine) and disrupts parasite mitochondrial function (piperaquine) to treat malaria. Used for Malaria treatment and prevention (Plasmodium falciparum and Plasmodium vivax).
At a glance
| Generic name | sulfadoxine pyrimethamine plus piperaquine |
|---|---|
| Also known as | sulfadoxine pyrimethamine, piperaquine phosphate |
| Sponsor | London School of Hygiene and Tropical Medicine |
| Drug class | Antifolate antimalarial combination with quinoline antimalarial |
| Target | Plasmodium dihydrofolate reductase, dihydropteroate synthase, and parasite mitochondria |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | Phase 3 |
Mechanism of action
Sulfadoxine and pyrimethamine are antifolate agents that inhibit dihydrofolate reductase and dihydropteroate synthase in Plasmodium parasites, blocking nucleotide synthesis essential for parasite survival. Piperaquine is a quinoline-type antimalarial that accumulates in parasite food vacuoles and generates reactive oxygen species, causing mitochondrial dysfunction and parasite death. The combination provides synergistic activity against multiple malaria species.
Approved indications
- Malaria treatment and prevention (Plasmodium falciparum and Plasmodium vivax)
Common side effects
- Nausea
- Vomiting
- Abdominal pain
- Headache
- Diarrhea
- Rash
Key clinical trials
- Perennial Malaria Chemoprevention in the Malaria Vaccine Era (PHASE4)
- Preventing Malaria in School Children to Protect the Whole Community in Rural Blantyre District, Malawi (PHASE4)
- Sulfadoxine-pyrimethamine Plus Dihydroartemisinin-piperaquine for Intermittent Preventive Treatment in Pregnancy (PHASE3)
- Evaluation of Vector and Chemoprevention-based Interventions to Reduce Malaria Burden in Urban Daaras of Touba, Senegal (PHASE4)
- Reducing the Burden of Malaria in HIV-uninfected Pregnant Women and Infants (PHASE3)
- Controlled Human Malaria Infection Transmission Model - Phase A (PHASE1, PHASE2)
- Enhancing Preventive Therapy of Malaria In Children With Sickle Cell Anemia in East Africa (EPiTOMISE) (PHASE4)
- Innovative Intermittent Preventive Treatment Approaches to Reduce Malaria Burden in School-age Children in Burkina Faso (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- sulfadoxine pyrimethamine plus piperaquine CI brief — competitive landscape report
- sulfadoxine pyrimethamine plus piperaquine updates RSS · CI watch RSS
- London School of Hygiene and Tropical Medicine portfolio CI
Frequently asked questions about sulfadoxine pyrimethamine plus piperaquine
What is sulfadoxine pyrimethamine plus piperaquine?
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Who makes sulfadoxine pyrimethamine plus piperaquine?
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What drug class is sulfadoxine pyrimethamine plus piperaquine in?
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Related
- Drug class: All Antifolate antimalarial combination with quinoline antimalarial drugs
- Target: All drugs targeting Plasmodium dihydrofolate reductase, dihydropteroate synthase, and parasite mitochondria
- Manufacturer: London School of Hygiene and Tropical Medicine — full pipeline
- Therapeutic area: All drugs in Infectious Disease
- Indication: Drugs for Malaria treatment and prevention (Plasmodium falciparum and Plasmodium vivax)
- Also known as: sulfadoxine pyrimethamine, piperaquine phosphate
- Compare: sulfadoxine pyrimethamine plus piperaquine vs similar drugs
- Pricing: sulfadoxine pyrimethamine plus piperaquine cost, discount & access