{"id":"sulfadoxine-pyrimethamine-plus-piperaquine","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Rash"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Sulfadoxine and pyrimethamine are antifolate agents that inhibit dihydrofolate reductase and dihydropteroate synthase in Plasmodium parasites, blocking nucleotide synthesis essential for parasite survival. Piperaquine is a quinoline-type antimalarial that accumulates in parasite food vacuoles and generates reactive oxygen species, causing mitochondrial dysfunction and parasite death. The combination provides synergistic activity against multiple malaria species.","oneSentence":"This combination drug inhibits parasite folate synthesis (sulfadoxine-pyrimethamine) and disrupts parasite mitochondrial function (piperaquine) to treat malaria.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:53:44.011Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Malaria treatment and prevention (Plasmodium falciparum and Plasmodium vivax)"}]},"trialDetails":[{"nctId":"NCT07322068","phase":"PHASE4","title":"Perennial Malaria Chemoprevention in the Malaria Vaccine Era","status":"NOT_YET_RECRUITING","sponsor":"Stanford University","startDate":"2026-09","conditions":"Malaria, Falciparum","enrollment":1290},{"nctId":"NCT06083688","phase":"PHASE4","title":"Preventing Malaria in School Children to Protect the Whole Community in Rural Blantyre District, Malawi","status":"ACTIVE_NOT_RECRUITING","sponsor":"Liverpool School of Tropical Medicine","startDate":"2024-10-14","conditions":"Malaria,Falciparum, Anemia in Children","enrollment":1000},{"nctId":"NCT05426434","phase":"PHASE3","title":"Sulfadoxine-pyrimethamine Plus Dihydroartemisinin-piperaquine for Intermittent Preventive Treatment in Pregnancy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Menzies School of Health Research","startDate":"2022-08-31","conditions":"Malaria, Malaria in Pregnancy, Pregnancy Related","enrollment":1172},{"nctId":"NCT06225297","phase":"PHASE4","title":"Evaluation of Vector and Chemoprevention-based Interventions to Reduce Malaria Burden in Urban Daaras of Touba, Senegal","status":"SUSPENDED","sponsor":"PATH","startDate":"2024-01-19","conditions":"Malaria","enrollment":4600},{"nctId":"NCT02163447","phase":"PHASE3","title":"Reducing the Burden of Malaria in HIV-uninfected Pregnant Women and Infants","status":"COMPLETED","sponsor":"Grant Dorsey, M.D, Ph.D.","startDate":"2014-06-23","conditions":"Malaria","enrollment":300},{"nctId":"NCT04280692","phase":"PHASE1, PHASE2","title":"Controlled Human Malaria Infection Transmission Model - 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Used for Malaria treatment and prevention (Plasmodium falciparum and Plasmodium vivax).","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}