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sulfadoxine pyrimethamine plus piperaquine — Competitive Intelligence Brief
phase 3
Antifolate antimalarial combination with quinoline antimalarial
Plasmodium dihydrofolate reductase, dihydropteroate synthase, and parasite mitochondria
Infectious Disease
Small molecule
Live · refreshed every 30 min
Target snapshot
sulfadoxine pyrimethamine plus piperaquine (sulfadoxine pyrimethamine plus piperaquine) — London School of Hygiene and Tropical Medicine. This combination drug inhibits parasite folate synthesis (sulfadoxine-pyrimethamine) and disrupts parasite mitochondrial function (piperaquine) to treat malaria.
Comparator set
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| sulfadoxine pyrimethamine plus piperaquine TARGET | sulfadoxine pyrimethamine plus piperaquine | London School of Hygiene and Tropical Medicine | phase 3 | Antifolate antimalarial combination with quinoline antimalarial | Plasmodium dihydrofolate reductase, dihydropteroate synthase, and parasite mitochondria |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
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Sponsor landscape (Antifolate antimalarial combination with quinoline antimalarial class)
- London School of Hygiene and Tropical Medicine · 1 drug in this class
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Cite this brief
Drug Landscape (2026). sulfadoxine pyrimethamine plus piperaquine — Competitive Intelligence Brief. https://druglandscape.com/ci/sulfadoxine-pyrimethamine-plus-piperaquine. Accessed 2026-05-18.
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