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Seroquel IR - quetiapine fumarate

AstraZeneca · FDA-approved active Small molecule

Seroquel IR - quetiapine fumarate is a Atypical antipsychotic Small molecule drug developed by AstraZeneca. It is currently FDA-approved for Schizophrenia, Bipolar I disorder (acute manic and depressive episodes), Major depressive disorder (as adjunctive therapy).

Quetiapine is an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT2A receptors in the brain.

Quetiapine is an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT2A receptors in the brain. Used for Schizophrenia, Bipolar I disorder (acute manic and depressive episodes), Major depressive disorder (as adjunctive therapy).

At a glance

Generic nameSeroquel IR - quetiapine fumarate
SponsorAstraZeneca
Drug classAtypical antipsychotic
TargetDopamine D2 receptor, Serotonin 5-HT2A receptor
ModalitySmall molecule
Therapeutic areaPsychiatry
PhaseFDA-approved

Mechanism of action

Quetiapine antagonizes dopamine D2 receptors and serotonin 5-HT2A receptors, which reduces psychotic symptoms and stabilizes mood. It also has activity at other receptors including histamine H1 and adrenergic receptors, contributing to its sedating properties and broader psychiatric effects.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about Seroquel IR - quetiapine fumarate

What is Seroquel IR - quetiapine fumarate?

Seroquel IR - quetiapine fumarate is a Atypical antipsychotic drug developed by AstraZeneca, indicated for Schizophrenia, Bipolar I disorder (acute manic and depressive episodes), Major depressive disorder (as adjunctive therapy).

How does Seroquel IR - quetiapine fumarate work?

Quetiapine is an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT2A receptors in the brain.

What is Seroquel IR - quetiapine fumarate used for?

Seroquel IR - quetiapine fumarate is indicated for Schizophrenia, Bipolar I disorder (acute manic and depressive episodes), Major depressive disorder (as adjunctive therapy), Generalized anxiety disorder.

Who makes Seroquel IR - quetiapine fumarate?

Seroquel IR - quetiapine fumarate is developed and marketed by AstraZeneca (see full AstraZeneca pipeline at /company/astrazeneca).

What drug class is Seroquel IR - quetiapine fumarate in?

Seroquel IR - quetiapine fumarate belongs to the Atypical antipsychotic class. See all Atypical antipsychotic drugs at /class/atypical-antipsychotic.

What development phase is Seroquel IR - quetiapine fumarate in?

Seroquel IR - quetiapine fumarate is FDA-approved (marketed).

What are the side effects of Seroquel IR - quetiapine fumarate?

Common side effects of Seroquel IR - quetiapine fumarate include Somnolence/sedation, Dry mouth, Dizziness, Headache, Constipation, Weight gain.

What does Seroquel IR - quetiapine fumarate target?

Seroquel IR - quetiapine fumarate targets Dopamine D2 receptor, Serotonin 5-HT2A receptor and is a Atypical antipsychotic.

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