Last reviewed 2026-04-19 · How we verify

Schizophrenia

Approved treatments

• Fluanxol
  Flupentixol works by blocking the histamine H1 receptor, which helps regulate various physiological processes including mood and cognition.
• Clopixol
  Clopixol works by blocking the 5-hydroxytryptamine receptor 6, which helps to regulate mood and reduce symptoms of schizophrenia.
• Sulpirid
  Sulpiride works by blocking the action of carbonic anhydrase 6, an enzyme that helps regulate the balance of acid and base in the brain.
• Abilify · Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
• Thorazine · Generic (originally Rhône-Poulenc/Sanofi)
• Lonasen · Dainippon Sumitomo Pharma Co., Ltd.
• Rexulti · Otsuka
• Zerdol · H. Lundbeck A/S
• Navane · Pfizer
• Seroquel · AstraZeneca
• Invega Sustenna · Johnson & Johnson
  Invega Sustenna works by blocking a specific channel in the brain that helps regulate electrical activity.
• Lybalvi · Alkermes Inc
  Lybalvi blocks the action of opioids at their receptor sites in the brain.
• Saphris · Hisamitsu
  Saphris works by blocking the action of serotonin at the 5-hydroxytryptamine receptor 2C.
• Thioridazine-2-Sulfoxide
• Cremin
• Vraylar · AbbVie
  Vraylar works by selectively blocking the D3 dopamine receptor, which helps regulate mood and behavior.
• Moditen Enanthate · Bristol-Myers Squibb
• Zyprexa · Eli Lilly
• Flupenthixol · National Institute on Drug Abuse (NIDA)
• Rexulti · University of Chicago
• Risperdal · Johnson & Johnson (Janssen)
  Atypical antipsychotic that antagonizes dopamine D2 and serotonin 5-HT2A receptors for schizophrenia and bipolar disorder.
• Geodon · Pfizer Inc.
  Atypical antipsychotic that antagonizes dopamine D2 and serotonin 5-HT2A receptors with the least metabolic side effects in its class.
• Caplyta · University of Chicago
• MESORIDAZINE BESYLATE
• Haldol · Johnson & Johnson (Janssen)
• Redeptin
  Redeptin works by blocking dopamine receptors in the brain.
• Oxypertin
  Oxypertine is thought to work by modulating neurotransmitter activity in the brain.
• Abilify · Generic (originally Otsuka/BMS)
  Third-generation antipsychotic that acts as a partial agonist at D2 and 5-HT1A receptors, stabilizing dopamine activity rather than simply blocking it.
• Aristada · Alkermes Inc
  Aristada works by blocking dopamine receptors in the brain to help regulate abnormal thought and behavior patterns.
• Latuda · Sunovion Pharms Inc
  Latuda works by blocking the action of serotonin at the 5-hydroxytryptamine receptor 2A, which helps to regulate mood and reduce symptoms of psychosis.
• Fanapt · Vanda Pharms Inc
  Fanapt works by blocking the action of serotonin at the 5-hydroxytryptamine receptor 2A, which helps to reduce symptoms of schizophrenia.
• Trilafon
• Compazine · GSK
• Taractan · Roche
• Caplyta · Intra-Cellular
  Caplyta works by binding to the 5-hydroxytryptamine receptor 2A, which helps to regulate dopamine and serotonin levels in the brain.
• Adasuve
• Moban
• Stelazine
• Prolixin Decanoate · Bristol-Myers Squibb
• Prolixin
• Seroquel · University of Pittsburgh
• Quetiapin · Sykehuset Innlandet HF
• Risperdal · Ohio State University
• Serdolect · University of Aarhus
• Zyprexa · Washington University School of Medicine

Competitive intelligence

For the full treatment-landscape CI brief — marketed leaders side-by-side, pipeline by phase, recent regulatory actions, sponsor landscape:

• Schizophrenia treatment landscape brief
• Schizophrenia treatment updates RSS