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Quetiapine Induced Neuroplasticity in Schizophrenic Patients: A Combined Transcranial Magnetic Stimulation (TMS) and Voxel-based Morphometry (VBM) Study
Aim of the study is to assess the effect of quetiapine treatment in neuroleptic naive, first-episode schizophrenic patients on aspects of functional and structural neuroplasticity assessed by means of transcranial magnetic stimulation and voxel-based morphometry. Main outcome measure is a change in gray matter density under quetiapine treatment from baseline to steady-state-treatment after 3 weeks.
Details
| Lead sponsor | University of Regensburg |
|---|---|
| Phase | Phase 4 |
| Status | COMPLETED |
| Enrolment | 30 |
| Start date | 2008-03 |
| Completion | 2011-03 |
Conditions
- Schizophrenia
Interventions
- Quetiapine
Primary outcomes
- Change of structural neuroplasticity (i.e. change in gray matter density) under treatment with quetiapine assessed by voxel-based morphometry. — 3 weeks
Countries
Germany