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Pregabalin & Magnesium sulphate
Pregabalin & Magnesium sulphate is a Anticonvulsant/analgesic combination Small molecule drug developed by National Cancer Institute, Egypt. It is currently in Phase 3 development for Chemotherapy-induced peripheral neuropathy (CIPN), Cancer-related neuropathic pain.
Pregabalin reduces neuronal calcium influx and neurotransmitter release while magnesium sulphate acts as an NMDA receptor antagonist, together modulating neuropathic pain and potentially chemotherapy-induced peripheral neuropathy.
Pregabalin reduces neuronal calcium influx and neurotransmitter release while magnesium sulphate acts as an NMDA receptor antagonist, together modulating neuropathic pain and potentially chemotherapy-induced peripheral neuropathy. Used for Chemotherapy-induced peripheral neuropathy (CIPN), Cancer-related neuropathic pain.
At a glance
| Generic name | Pregabalin & Magnesium sulphate |
|---|---|
| Sponsor | National Cancer Institute, Egypt |
| Drug class | Anticonvulsant/analgesic combination |
| Target | Alpha-2-delta calcium channel subunit; NMDA receptor |
| Modality | Small molecule |
| Therapeutic area | Oncology; Neurology |
| Phase | Phase 3 |
Mechanism of action
Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels, decreasing excitatory neurotransmitter release in the central and peripheral nervous systems. Magnesium sulphate blocks NMDA receptors and modulates calcium homeostasis. This combination is hypothesized to provide synergistic neuroprotection and pain relief, particularly in cancer-related neuropathic conditions.
Approved indications
- Chemotherapy-induced peripheral neuropathy (CIPN)
- Cancer-related neuropathic pain
Common side effects
- Dizziness
- Somnolence
- Peripheral edema
- Hypermagnesemia (with magnesium sulphate)
Key clinical trials
- Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair (PHASE4)
- Does IV Magnesium Improve Quality of Recovery With ERAS Protocols in Laparoscopic Colorectal Surgery? (PHASE3)
- Multimodal Versus Opioid aNalgesia in carDiAc Surgery (PHASE4)
- Comparison Between Oxycodone and Pregabalin as Preemptive Analgesia (PHASE2, PHASE3)
- Comparison Between Pregabalin and Magnesium Sulfate in Hypotensive Anaesthesia (PHASE1, PHASE2)
- Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC (PHASE4)
- Analgesic Potentials of Preoperative Pregabalin,Magnesium Sulphate and Their Combination in Acute Post-thoracotomy Pain (PHASE3)
- Erector Spinae Plane Block in Post-herpetic Neuralgia (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Pregabalin & Magnesium sulphate CI brief — competitive landscape report
- Pregabalin & Magnesium sulphate updates RSS · CI watch RSS
- National Cancer Institute, Egypt portfolio CI
Frequently asked questions about Pregabalin & Magnesium sulphate
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Related
- Drug class: All Anticonvulsant/analgesic combination drugs
- Target: All drugs targeting Alpha-2-delta calcium channel subunit; NMDA receptor
- Manufacturer: National Cancer Institute, Egypt — full pipeline
- Therapeutic area: All drugs in Oncology; Neurology
- Indication: Drugs for Chemotherapy-induced peripheral neuropathy (CIPN)
- Indication: Drugs for Cancer-related neuropathic pain
- Compare: Pregabalin & Magnesium sulphate vs similar drugs
- Pricing: Pregabalin & Magnesium sulphate cost, discount & access