{"id":"pregabalin-magnesium-sulphate","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Somnolence"},{"rate":null,"effect":"Peripheral edema"},{"rate":null,"effect":"Hypermagnesemia (with magnesium sulphate)"}]},"_chembl":{"chemblId":"CHEMBL1059","moleculeType":"Small molecule","molecularWeight":"159.23"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels, decreasing excitatory neurotransmitter release in the central and peripheral nervous systems. Magnesium sulphate blocks NMDA receptors and modulates calcium homeostasis. This combination is hypothesized to provide synergistic neuroprotection and pain relief, particularly in cancer-related neuropathic conditions.","oneSentence":"Pregabalin reduces neuronal calcium influx and neurotransmitter release while magnesium sulphate acts as an NMDA receptor antagonist, together modulating neuropathic pain and potentially chemotherapy-induced peripheral neuropathy.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:29:58.575Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chemotherapy-induced peripheral neuropathy (CIPN)"},{"name":"Cancer-related neuropathic pain"}]},"trialDetails":[{"nctId":"NCT04894864","phase":"PHASE4","title":"Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair","status":"RECRUITING","sponsor":"University of Crete","startDate":"2020-10-08","conditions":"Elective Surgical Procedures, Postoperative Pain, Anesthesia","enrollment":40},{"nctId":"NCT05021263","phase":"PHASE3","title":"Does IV Magnesium Improve Quality of Recovery With ERAS Protocols in Laparoscopic Colorectal Surgery?","status":"COMPLETED","sponsor":"Thomas Jefferson University","startDate":"2022-05-27","conditions":"Colo-rectal Cancer, Anesthesia","enrollment":90},{"nctId":"NCT04987372","phase":"PHASE4","title":"Multimodal Versus Opioid aNalgesia in carDiAc Surgery","status":"COMPLETED","sponsor":"University Hospital, Ghent","startDate":"2019-01-21","conditions":"Postoperative Pain, Postoperative Delirium","enrollment":100},{"nctId":"NCT05389813","phase":"PHASE2, PHASE3","title":"Comparison Between Oxycodone and Pregabalin as Preemptive Analgesia","status":"UNKNOWN","sponsor":"An-Najah National University","startDate":"2021-08-15","conditions":"Anesthesia","enrollment":150},{"nctId":"NCT05442931","phase":"PHASE1, PHASE2","title":"Comparison Between Pregabalin and Magnesium Sulfate in Hypotensive Anaesthesia","status":"UNKNOWN","sponsor":"Minia University","startDate":"2022-05-01","conditions":"Functional Endoscopic Sinus Surgery","enrollment":60},{"nctId":"NCT05172739","phase":"PHASE4","title":"Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC","status":"RECRUITING","sponsor":"University of Crete","startDate":"2021-10-01","conditions":"Systemic Inflammatory Response Syndrome, Postoperative Pain, Acute, Postoperative Pain, Chronic","enrollment":70},{"nctId":"NCT02678117","phase":"PHASE3","title":"Analgesic Potentials of Preoperative Pregabalin,Magnesium Sulphate and Their Combination in Acute Post-thoracotomy Pain","status":"COMPLETED","sponsor":"National Cancer Institute, Egypt","startDate":"2015-07","conditions":"Postoperative Pain","enrollment":120},{"nctId":"NCT04546334","phase":"NA","title":"Erector Spinae Plane Block in Post-herpetic Neuralgia","status":"COMPLETED","sponsor":"Tanta University","startDate":"2020-09-26","conditions":"Postherpetic Neuralgia","enrollment":90},{"nctId":"NCT03610217","phase":"NA","title":"Pragmatic Clinical Trials in Scleroderma","status":"UNKNOWN","sponsor":"University of West London","startDate":"2018-10","conditions":"Scleroderma, Systemic, Sclerosis, Systemic","enrollment":400}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Pregabalin & Magnesium sulphate","genericName":"Pregabalin & Magnesium sulphate","companyName":"National Cancer Institute, Egypt","companyId":"national-cancer-institute-egypt","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pregabalin reduces neuronal calcium influx and neurotransmitter release while magnesium sulphate acts as an NMDA receptor antagonist, together modulating neuropathic pain and potentially chemotherapy-induced peripheral neuropathy. Used for Chemotherapy-induced peripheral neuropathy (CIPN), Cancer-related neuropathic pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}