Analgesic Potentials of Preoperative Oral Pregabalin,Intravenous Magnesium Sulphate and Their Combination in Acute Post-thoracotomy Pain.(Randomized,Double-Blind Study)

NCT02678117 Phase 3 COMPLETED

This study evaluates the effect of giving preoperative adjuvant drug as pregabalin or magnesium sulphate or a combination of both drugs to decrease postoperative morphine consumption and pain intensity in the first 24 hours in postoperative period . quarter of patients receive single dose oral pregabalin 300mg 1 hour preoperatively ,other quarter receive single intravenous Magnesium sulphate 50mg per Kg over 200ml saline over 20 minutes preoperatively , other quarter receive combination of both drugs , the last quarter receive placebo drugs . All patients receive 0.1mg per Kg intravenous morphine sulphate intraoperatively

Details

Lead sponsor	National Cancer Institute, Egypt
Phase	Phase 3
Status	COMPLETED
Enrolment	120
Start date	2015-07
Completion	2019-12

Conditions

• Postoperative Pain

Interventions

• Pregabalin & Placebo
• Magnesium sulphate & Placebo
• Pregabalin & Magnesium sulphate
• Placebo

Primary outcomes

• Total morphine consumption — First 24 hours in postoperative period
  patients are given regular intravenous morphine through patient controlled analgesia (PCA) and morphine consumption calculated from the PCA device

Countries

Egypt