Last reviewed · How we verify
prednisolone and chlorambucil
Prednisolone is a corticosteroid that suppresses the immune system and reduces inflammation, while chlorambucil is an alkylating agent that interferes with DNA replication and induces cell death.
Prednisolone is a corticosteroid that suppresses the immune system and reduces inflammation, while chlorambucil is an alkylating agent that interferes with DNA replication and induces cell death. Used for Chronic lymphocytic leukemia.
At a glance
| Generic name | prednisolone and chlorambucil |
|---|---|
| Sponsor | Hospital Authority, Hong Kong |
| Drug class | Corticosteroid and alkylating agent |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
Prednisolone works by inhibiting the production of inflammatory cytokines and inducing apoptosis in immune cells. Chlorambucil, on the other hand, forms covalent bonds with DNA, leading to cross-linking and DNA strand breaks, ultimately causing cell death.
Approved indications
- Chronic lymphocytic leukemia
Common side effects
- Nausea
- Vomiting
- Diarrhea
- Fatigue
- Infection
Key clinical trials
- Chemotherapy in Treating Patients With Newly Diagnosed Chronic Lymphocytic Leukemia (PHASE3)
- Combination Chemotherapy in Treating Patients With Advanced Hodgkin's Disease (PHASE3)
- Mycophenolate Mofetil in Membranous Nephropathy and Focal Segmental (PHASE3)
- Combination Chemotherapy in Treating Patients With HIV-Related Non-Hodgkin's Lymphoma (PHASE2)
- Combination Chemotherapy With or Without Radiation Therapy and Peripheral Stem Cell Transplant in Treating Children With Hodgkin's Lymphoma (PHASE2)
- Combination Chemotherapy and/or Radiation Therapy in Treating Young Patients With Hodgkin's Lymphoma (NA)
- Radiation Therapy or Combination Chemotherapy in Treating Young Patients With Hodgkin's Lymphoma (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- prednisolone and chlorambucil CI brief — competitive landscape report
- prednisolone and chlorambucil updates RSS · CI watch RSS
- Hospital Authority, Hong Kong portfolio CI