{"id":"prednisolone-and-chlorambucil","safety":{"commonSideEffects":[{"rate":"10-30%","effect":"Nausea"},{"rate":"5-20%","effect":"Vomiting"},{"rate":"5-15%","effect":"Diarrhea"},{"rate":"10-30%","effect":"Fatigue"},{"rate":"5-20%","effect":"Infection"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Prednisolone works by inhibiting the production of inflammatory cytokines and inducing apoptosis in immune cells. Chlorambucil, on the other hand, forms covalent bonds with DNA, leading to cross-linking and DNA strand breaks, ultimately causing cell death.","oneSentence":"Prednisolone is a corticosteroid that suppresses the immune system and reduces inflammation, while chlorambucil is an alkylating agent that interferes with DNA replication and induces cell death.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:52:00.409Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic lymphocytic leukemia"}]},"trialDetails":[{"nctId":"NCT00004218","phase":"PHASE3","title":"Chemotherapy in Treating Patients With Newly Diagnosed Chronic Lymphocytic Leukemia","status":"COMPLETED","sponsor":"Leukemia Research Fund","startDate":"1999-10","conditions":"Leukemia","enrollment":""},{"nctId":"NCT00003421","phase":"PHASE3","title":"Combination Chemotherapy in Treating Patients With Advanced Hodgkin's Disease","status":"COMPLETED","sponsor":"Medical Research Council","startDate":"1998-06","conditions":"Lymphoma","enrollment":800},{"nctId":"NCT00404833","phase":"PHASE3","title":"Mycophenolate Mofetil in Membranous Nephropathy and Focal Segmental","status":"COMPLETED","sponsor":"Hospital Authority, Hong Kong","startDate":"2003-01","conditions":"Glomerulonephritis, Membranous, Glomerulosclerosis, Focal","enrollment":16},{"nctId":"NCT00002905","phase":"PHASE2","title":"Combination Chemotherapy in Treating Patients With HIV-Related Non-Hodgkin's Lymphoma","status":"UNKNOWN","sponsor":"Centro di Riferimento Oncologico - Aviano","startDate":"1995-06","conditions":"Lymphoma","enrollment":20},{"nctId":"NCT00025064","phase":"PHASE2","title":"Combination Chemotherapy With or Without Radiation Therapy and Peripheral Stem Cell Transplant in Treating Children With Hodgkin's Lymphoma","status":"UNKNOWN","sponsor":"Children's Cancer and Leukaemia Group","startDate":"2000-01","conditions":"Lymphoma","enrollment":260},{"nctId":"NCT00417014","phase":"NA","title":"Combination Chemotherapy and/or Radiation Therapy in Treating Young Patients With Hodgkin's Lymphoma","status":"UNKNOWN","sponsor":"Children's Cancer and Leukaemia Group","startDate":"","conditions":"Lymphoma","enrollment":358},{"nctId":"NCT00416377","phase":"NA","title":"Radiation Therapy or Combination Chemotherapy in Treating Young Patients With Hodgkin's Lymphoma","status":"UNKNOWN","sponsor":"Children's Cancer and Leukaemia Group","startDate":"","conditions":"Lymphoma","enrollment":353}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":91,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"prednisolone and chlorambucil","genericName":"prednisolone and chlorambucil","companyName":"Hospital Authority, Hong Kong","companyId":"hospital-authority-hong-kong","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Prednisolone is a corticosteroid that suppresses the immune system and reduces inflammation, while chlorambucil is an alkylating agent that interferes with DNA replication and induces cell death. Used for Chronic lymphocytic leukemia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}