Chronic Lymphocytic Leukemia Trial 4: A Randomized Comparison of Chlorambucil, Fludarabine and Fludarabine Plus Cyclophosphamide

NCT00004218 Phase 3 COMPLETED

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. It is not yet known which regimen of chemotherapy is more effective for chronic lymphocytic leukemia. PURPOSE: This randomized phase III trial is studying chlorambucil to see how well it works compared to fludarabine and cyclophosphamide or fludarabine alone in treating patients with newly diagnosed chronic lymphocytic leukemia.

Details

Lead sponsor	Leukemia Research Fund
Phase	Phase 3
Status	COMPLETED
Start date	1999-10
Completion	2007-07

Conditions

• Leukemia

Interventions

• chlorambucil
• cyclophosphamide
• doxorubicin hydrochloride
• fludarabine phosphate
• prednisolone
• vincristine sulfate

Countries

Argentina, Croatia, Greece, Ireland, Italy, New Zealand, Russia, United Kingdom