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low molecular weight heparin, 5-FU
low molecular weight heparin, 5-FU is a Anticoagulant Small molecule drug developed by Shahid Beheshti University of Medical Sciences. It is currently in Phase 3 development for Prophylaxis and treatment of deep vein thrombosis and pulmonary embolism, Prophylaxis and treatment of atrial fibrillation for stroke prevention.
Low molecular weight heparin works by inhibiting Factor Xa and thrombin, preventing blood clot formation.
Low molecular weight heparin works by inhibiting Factor Xa and thrombin, preventing blood clot formation. Used for Prophylaxis and treatment of deep vein thrombosis and pulmonary embolism, Prophylaxis and treatment of atrial fibrillation for stroke prevention.
At a glance
| Generic name | low molecular weight heparin, 5-FU |
|---|---|
| Sponsor | Shahid Beheshti University of Medical Sciences |
| Drug class | Anticoagulant |
| Target | Factor Xa, Thrombin |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 3 |
Mechanism of action
Low molecular weight heparin is a type of anticoagulant that selectively inhibits Factor Xa and thrombin, which are key enzymes in the coagulation cascade. This inhibition prevents the formation of blood clots, which can cause serious health problems such as deep vein thrombosis and pulmonary embolism.
Approved indications
- Prophylaxis and treatment of deep vein thrombosis and pulmonary embolism
- Prophylaxis and treatment of atrial fibrillation for stroke prevention
Common side effects
- Bleeding
- Hypersensitivity reactions
- Thrombocytopenia
Key clinical trials
- Efficacy of 5-fluorouracil and Low Molecular Weight Heparin in High-risk Pediatric Retinal Detachment (NA)
- Prophylactic Intravitreal 5-Fluorouracil and Heparin to Prevent PVR in High-risk Patients With Retinal Detachment. (PHASE3)
- The Role of Low Molecular Weight Heparins in Hepatocellular Carcinoma (PHASE2, PHASE3)
- Chemotherapy With or Without Enoxaparin in Pancreatic Cancer (PHASE2, PHASE3)
- FOLFIRI + Bevacizumab With or Without Dalteparin in First Line Treatment of Advanced Colorectal Cancer (PHASE2)
- Oral Colchicine Combined With Intravitreal Infusion of Dexamethasone, LMW Heparin and 5-FU for Management of Proliferative Vitreoretinopathy (PVR) (PHASE3)
- The Effect of 5-FU and LMW Heparin on the Rate of Retinal Redetachment After Silicone Oil Removal in Cases of PVR (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- low molecular weight heparin, 5-FU CI brief — competitive landscape report
- low molecular weight heparin, 5-FU updates RSS · CI watch RSS
- Shahid Beheshti University of Medical Sciences portfolio CI
Frequently asked questions about low molecular weight heparin, 5-FU
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Related
- Drug class: All Anticoagulant drugs
- Target: All drugs targeting Factor Xa, Thrombin
- Manufacturer: Shahid Beheshti University of Medical Sciences — full pipeline
- Therapeutic area: All drugs in Cardiovascular
- Indication: Drugs for Prophylaxis and treatment of deep vein thrombosis and pulmonary embolism
- Indication: Drugs for Prophylaxis and treatment of atrial fibrillation for stroke prevention
- Compare: low molecular weight heparin, 5-FU vs similar drugs
- Pricing: low molecular weight heparin, 5-FU cost, discount & access