{"id":"low-molecular-weight-heparin-5-fu","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Bleeding"},{"rate":"1-5%","effect":"Hypersensitivity reactions"},{"rate":"1-5%","effect":"Thrombocytopenia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Low molecular weight heparin is a type of anticoagulant that selectively inhibits Factor Xa and thrombin, which are key enzymes in the coagulation cascade. This inhibition prevents the formation of blood clots, which can cause serious health problems such as deep vein thrombosis and pulmonary embolism.","oneSentence":"Low molecular weight heparin works by inhibiting Factor Xa and thrombin, preventing blood clot formation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:19:38.305Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prophylaxis and treatment of deep vein thrombosis and pulmonary embolism"},{"name":"Prophylaxis and treatment of atrial fibrillation for stroke prevention"}]},"trialDetails":[{"nctId":"NCT06166914","phase":"NA","title":"Efficacy of 5-fluorouracil and Low Molecular Weight Heparin in High-risk Pediatric Retinal Detachment","status":"COMPLETED","sponsor":"Alexandria University","startDate":"2021-10-21","conditions":"Retinal Detachment, Proliferative Vitreoretinopathy","enrollment":42},{"nctId":"NCT02834559","phase":"PHASE3","title":"Prophylactic Intravitreal 5-Fluorouracil and Heparin to Prevent PVR in High-risk Patients With Retinal Detachment.","status":"COMPLETED","sponsor":"Universitätsklinikum Köln","startDate":"2016-10-27","conditions":"Rhegmatogenous Retinal Detachment, High-risk for Proliferative Vitreoretinopathy (PVR)","enrollment":326},{"nctId":"NCT00827554","phase":"PHASE2, PHASE3","title":"The Role of Low Molecular Weight Heparins in Hepatocellular Carcinoma","status":"COMPLETED","sponsor":"Eastern Hepatobiliary Surgery Hospital","startDate":"2008-12","conditions":"Hepatocellular Carcinoma","enrollment":100},{"nctId":"NCT00785421","phase":"PHASE2, PHASE3","title":"Chemotherapy With or Without Enoxaparin in Pancreatic Cancer","status":"COMPLETED","sponsor":"CONKO-Studiengruppe","startDate":"2004-04","conditions":"Pancreatic Cancer","enrollment":312},{"nctId":"NCT00323011","phase":"PHASE2","title":"FOLFIRI + Bevacizumab With or Without Dalteparin in First Line Treatment of Advanced Colorectal Cancer","status":"TERMINATED","sponsor":"University of Southern California","startDate":"2006-05","conditions":"Colorectal Cancer","enrollment":5},{"nctId":"NCT00370760","phase":"PHASE3","title":"Oral Colchicine Combined With Intravitreal Infusion of Dexamethasone, LMW Heparin and 5-FU for Management of Proliferative Vitreoretinopathy (PVR)","status":"UNKNOWN","sponsor":"Shahid Beheshti University of Medical Sciences","startDate":"2006-09","conditions":"Proliferative Vitreoretinopathy","enrollment":""},{"nctId":"NCT00371020","phase":"PHASE3","title":"The Effect of 5-FU and LMW Heparin on the Rate of Retinal Redetachment After Silicone Oil Removal in Cases of PVR","status":"UNKNOWN","sponsor":"Shahid Beheshti University of Medical Sciences","startDate":"2005-02","conditions":"Proliferative Vitreoretinopathy","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":18,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"low molecular weight heparin, 5-FU","genericName":"low molecular weight heparin, 5-FU","companyName":"Shahid Beheshti University of Medical Sciences","companyId":"shahid-beheshti-university-of-medical-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Low molecular weight heparin works by inhibiting Factor Xa and thrombin, preventing blood clot formation. Used for Prophylaxis and treatment of deep vein thrombosis and pulmonary embolism, Prophylaxis and treatment of atrial fibrillation for stroke prevention.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}