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Levobupivacaine lidocaine spinal anesthesia
Levobupivacaine and lidocaine are local anesthetics that block sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce reversible loss of sensation.
Levobupivacaine and lidocaine are local anesthetics that block sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce reversible loss of sensation. Used for Spinal anesthesia for surgical procedures.
At a glance
| Generic name | Levobupivacaine lidocaine spinal anesthesia |
|---|---|
| Also known as | Chirocaine, Lidocaine |
| Sponsor | Diskapi Teaching and Research Hospital |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Both levobupivacaine and lidocaine are amide-type local anesthetics that inhibit voltage-gated sodium channels in the neuronal membrane, preventing depolarization and nerve impulse transmission. When administered intrathecally for spinal anesthesia, they diffuse across the dura mater to block sensory and motor nerves in the spinal cord, producing rapid onset of anesthesia in the lower body. Levobupivacaine is the S-enantiomer of bupivacaine and has a longer duration of action and potentially improved safety profile compared to lidocaine.
Approved indications
- Spinal anesthesia for surgical procedures
- Regional anesthesia for lower abdominal and lower extremity surgery
Common side effects
- Hypotension
- Bradycardia
- Headache (post-dural puncture)
- Nausea and vomiting
- Neurological toxicity (at high doses)
- Cardiovascular toxicity (at high doses)
Key clinical trials
- Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy (NA)
- Intrathecal Morphine Versus Epidural Analgesia for Open Colon Surgery (PHASE4)
- Intrathecal Morphine Versus Epidural Analgesia for Laparoscopic Colon Surgery (PHASE4)
- Comparison Between Epidural Analgesia and Intrathecal Opioid Analgesia for Pain Management in Open Nephrectomy (PHASE1)
- The Effects of Method of Anaesthesia on the Safety and Effectiveness of Radical Retropubic Prostatectomy (NA)
- Sedation Complications in Urology During Spinal Anesthesia With Dexmedetomidine or Midazolam Regarding OSA Risk (PHASE4)
- Ligation and Hemorrhoidopexy Technique Versus Ligation of Hemorrhoidal Arteries Using Ultrasound for Hemorrhoids (NA)
- Decision Support for Intraoperative Low Blood Pressure (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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