{"id":"levobupivacaine-lidocaine-spinal-anesthesia","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Headache (post-dural puncture)"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Neurological toxicity (at high doses)"},{"rate":null,"effect":"Cardiovascular toxicity (at high doses)"}]},"_chembl":{"chemblId":"CHEMBL1201193","moleculeType":"Small molecule","molecularWeight":"288.44"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Both levobupivacaine and lidocaine are amide-type local anesthetics that inhibit voltage-gated sodium channels in the neuronal membrane, preventing depolarization and nerve impulse transmission. When administered intrathecally for spinal anesthesia, they diffuse across the dura mater to block sensory and motor nerves in the spinal cord, producing rapid onset of anesthesia in the lower body. Levobupivacaine is the S-enantiomer of bupivacaine and has a longer duration of action and potentially improved safety profile compared to lidocaine.","oneSentence":"Levobupivacaine and lidocaine are local anesthetics that block sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce reversible loss of sensation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:33:54.224Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Spinal anesthesia for surgical procedures"},{"name":"Regional anesthesia for lower abdominal and lower extremity surgery"}]},"trialDetails":[{"nctId":"NCT07084753","phase":"NA","title":"Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy","status":"NOT_YET_RECRUITING","sponsor":"IVO JURISIC","startDate":"2025-07-30","conditions":"Obese Patients, Bariatric Surgical Pain, Bariatric Surgery (Sleeve Gastrectomy )","enrollment":36},{"nctId":"NCT06935708","phase":"PHASE4","title":"Intrathecal Morphine Versus Epidural Analgesia for Open Colon Surgery","status":"RECRUITING","sponsor":"Meri Mirceta","startDate":"2025-04-08","conditions":"Colorectal Carcinoma, Analgesia, Postoperative, Laparotomy","enrollment":98},{"nctId":"NCT06881563","phase":"PHASE4","title":"Intrathecal Morphine Versus Epidural Analgesia for Laparoscopic Colon Surgery","status":"NOT_YET_RECRUITING","sponsor":"Meri Mirceta","startDate":"2025-03","conditions":"Postoperative Pain, Analgesia, Colorectal Cancer","enrollment":98},{"nctId":"NCT06595329","phase":"PHASE1","title":"Comparison Between Epidural Analgesia and Intrathecal Opioid Analgesia for Pain Management in Open Nephrectomy","status":"RECRUITING","sponsor":"University Hospital of Split","startDate":"2025-01-15","conditions":"Pain, Renal Cancer, Surgical Procedure, Unspecified","enrollment":40},{"nctId":"NCT05566405","phase":"NA","title":"The Effects of Method of Anaesthesia on the Safety and Effectiveness of Radical Retropubic Prostatectomy","status":"COMPLETED","sponsor":"Sismanoglio General Hospital","startDate":"2020-07-27","conditions":"Prostatic Neoplasm","enrollment":60},{"nctId":"NCT04817033","phase":"PHASE4","title":"Sedation Complications in Urology During Spinal Anesthesia With Dexmedetomidine or Midazolam Regarding OSA Risk","status":"COMPLETED","sponsor":"University Hospital of Split","startDate":"2021-04-01","conditions":"Anesthesia, Anesthesia Complication, Osa Syndrome","enrollment":115},{"nctId":"NCT03298997","phase":"NA","title":"Ligation and Hemorrhoidopexy Technique Versus Ligation of Hemorrhoidal Arteries Using Ultrasound for Hemorrhoids","status":"COMPLETED","sponsor":"Larissa University Hospital","startDate":"2017-10-01","conditions":"Hemorrhoids","enrollment":60},{"nctId":"NCT02726620","phase":"NA","title":"Decision Support for Intraoperative Low Blood Pressure","status":"COMPLETED","sponsor":"Vanderbilt University Medical Center","startDate":"2017-01-05","conditions":"Hypotension","enrollment":22435},{"nctId":"NCT01675895","phase":"PHASE4","title":"Addition of Lidocaine to Levobupivacaine Reduces Intrathecal Block Duration","status":"COMPLETED","sponsor":"Diskapi Teaching and Research Hospital","startDate":"2009-07","conditions":"Benign Prostate Hyperplasia","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Chirocaine","Lidocaine"],"phase":"marketed","status":"active","brandName":"Levobupivacaine lidocaine spinal anesthesia","genericName":"Levobupivacaine lidocaine spinal anesthesia","companyName":"Diskapi Teaching and Research Hospital","companyId":"diskapi-teaching-and-research-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Levobupivacaine and lidocaine are local anesthetics that block sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce reversible loss of sensation. Used for Spinal anesthesia for surgical procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}