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Ketamine with propofol
Ketamine with propofol is a Anesthetic combination Small molecule drug developed by Henry M. Jackson Foundation for the Advancement of Military Medicine. It is currently FDA-approved for Procedural sedation and anesthesia in emergency and military medical settings, Rapid sequence intubation.
Ketamine and propofol together provide rapid-onset anesthesia and analgesia by blocking NMDA receptors and enhancing GABAergic inhibition, respectively.
Ketamine and propofol together provide rapid-onset anesthesia and analgesia by blocking NMDA receptors and enhancing GABAergic inhibition, respectively. Used for Procedural sedation and anesthesia in emergency and military medical settings, Rapid sequence intubation.
At a glance
| Generic name | Ketamine with propofol |
|---|---|
| Sponsor | Henry M. Jackson Foundation for the Advancement of Military Medicine |
| Drug class | Anesthetic combination |
| Target | NMDA receptor (ketamine); GABA-A receptor (propofol) |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Ketamine is a non-competitive NMDA receptor antagonist that produces dissociative anesthesia and analgesia while maintaining airway reflexes. Propofol is a GABAergic agonist that enhances inhibitory neurotransmission, producing sedation and hypnosis. The combination leverages ketamine's analgesic and dissociative properties with propofol's rapid onset and offset for balanced anesthesia.
Approved indications
- Procedural sedation and anesthesia in emergency and military medical settings
- Rapid sequence intubation
Common side effects
- Hypotension
- Respiratory depression
- Emergence reactions (ketamine-related)
- Bradycardia
- Apnea
Key clinical trials
- Correlating EEG Dynamics With Consciousness Alteration Under Anesthesia
- Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery. (NA)
- Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery (NA)
- Magnesium Sulfate Versus Other Anesthesia Drugs to Reduce Agitation After Adenotonsillectomy in Pediatric Patients (NA)
- Transition From Acute to Chronic Opioid Use and Chronic Pain (EARLY_PHASE1)
- Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients
- Intravenous Lidocaine Plus Port-Site Ropivacaine for Recovery After Laparoscopic Surgery (PHASE3)
- Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS) (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ketamine with propofol CI brief — competitive landscape report
- Ketamine with propofol updates RSS · CI watch RSS
- Henry M. Jackson Foundation for the Advancement of Military Medicine portfolio CI
Frequently asked questions about Ketamine with propofol
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Related
- Drug class: All Anesthetic combination drugs
- Target: All drugs targeting NMDA receptor (ketamine); GABA-A receptor (propofol)
- Manufacturer: Henry M. Jackson Foundation for the Advancement of Military Medicine — full pipeline
- Therapeutic area: All drugs in Anesthesiology
- Indication: Drugs for Procedural sedation and anesthesia in emergency and military medical settings
- Indication: Drugs for Rapid sequence intubation
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing