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The combination leverages ketamine's analgesic and dissociative properties with propofol's rapid onset and offset for balanced anesthesia.","oneSentence":"Ketamine and propofol together provide rapid-onset anesthesia and analgesia by blocking NMDA receptors and enhancing GABAergic inhibition, respectively.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:51:09.518Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Procedural sedation and anesthesia in emergency and military medical settings"},{"name":"Rapid sequence intubation"}]},"trialDetails":[{"nctId":"NCT07410702","phase":"","title":"Correlating EEG Dynamics With Consciousness Alteration Under Anesthesia","status":"RECRUITING","sponsor":"Huazhong University of Science and Technology","startDate":"2026-02-10","conditions":"Altered State of Consciousness, General Anesthetics","enrollment":250},{"nctId":"NCT07486336","phase":"NA","title":"Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery.","status":"NOT_YET_RECRUITING","sponsor":"Ente Ospedaliero Ospedali Galliera","startDate":"2026-09-01","conditions":"Fraily, Abdominal Surgery, Postoperative Cognitive Dysfunction (POCD)","enrollment":100},{"nctId":"NCT07337135","phase":"NA","title":"Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery","status":"COMPLETED","sponsor":"Hospital dos Lusíadas","startDate":"2023-10-02","conditions":"Morbid Obesity, Postoperative Pain, Opioid Free Anesthesia","enrollment":60},{"nctId":"NCT07433231","phase":"NA","title":"Magnesium Sulfate Versus Other Anesthesia Drugs to Reduce Agitation After Adenotonsillectomy in Pediatric Patients","status":"COMPLETED","sponsor":"Ayfer Kaya Gök","startDate":"2023-11-01","conditions":"Anesthesia Emergence Delirium, Adenotonsillar Hypertrophy","enrollment":100},{"nctId":"NCT07211399","phase":"EARLY_PHASE1","title":"Transition From Acute to Chronic Opioid Use and Chronic Pain","status":"NOT_YET_RECRUITING","sponsor":"Jacques E. 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