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intra-articular botulinum toxin type a
intra-articular botulinum toxin type a is a Botulinum toxin Small molecule drug developed by Minneapolis Veterans Affairs Medical Center. It is currently in Phase 3 development for Treatment of chronic low back pain.
Intra-articular botulinum toxin type A works by inhibiting the release of acetylcholine, a neurotransmitter that causes muscle contraction.
Intra-articular botulinum toxin type A works by inhibiting the release of acetylcholine, a neurotransmitter that causes muscle contraction. Used for Treatment of chronic low back pain.
At a glance
| Generic name | intra-articular botulinum toxin type a |
|---|---|
| Sponsor | Minneapolis Veterans Affairs Medical Center |
| Drug class | Botulinum toxin |
| Target | Acetylcholine release |
| Modality | Small molecule |
| Therapeutic area | Rheumatology |
| Phase | Phase 3 |
Mechanism of action
By blocking acetylcholine release, intra-articular botulinum toxin type A reduces muscle spasms and inflammation in joints, providing pain relief and improving joint mobility. This mechanism is particularly effective in treating conditions characterized by excessive muscle contraction, such as arthritis and joint pain.
Approved indications
- Treatment of chronic low back pain
Common side effects
- Pain at injection site
Key clinical trials
- Botulinum Toxin Versus Platelet Rich Fibrin for TMJ Internal Derangement (NA)
- Intra Articular Injection of Botulinum Toxin Versus Corticoids in Gonarthrosis (PHASE2)
- Efficacy of an Intra-articular Injection of Botulinum Toxin A Associated With Splinting for Base-of-thumb Osteoarthritis (PHASE2, PHASE3)
- Efficacy of Two Ultrasound-guided Intra-articular Injections of Botox® Combined With Custom-made Rigid Splinting in Painful Base-of-thumb Osteoarthritis. (PHASE2, PHASE3)
- I-PRF After Arthrocentesis Plus Botox Injection to Lateral Pterygoid Muscle in Treatment of Anterior Disc Displacement (NA)
- Trial Comparing Botulin Toxin Versus Hyaluronic Acid by Intra-articular Injection for the Treatment of Painful Knee Osteoarthritis (PHASE2)
- Safety and Efficacy of Botulinum Toxin A Injection in Patients With Painful Artificial Knee Arthroplasty (TKA) (PHASE2)
- BOTOX® Efficacy and Safety in the Treatment of Knee Osteoarthritis (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- intra-articular botulinum toxin type a CI brief — competitive landscape report
- intra-articular botulinum toxin type a updates RSS · CI watch RSS
- Minneapolis Veterans Affairs Medical Center portfolio CI
Frequently asked questions about intra-articular botulinum toxin type a
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Related
- Drug class: All Botulinum toxin drugs
- Target: All drugs targeting Acetylcholine release
- Manufacturer: Minneapolis Veterans Affairs Medical Center — full pipeline
- Therapeutic area: All drugs in Rheumatology
- Indication: Drugs for Treatment of chronic low back pain
- Compare: intra-articular botulinum toxin type a vs similar drugs
- Pricing: intra-articular botulinum toxin type a cost, discount & access