{"id":"intra-articular-botulinum-toxin-type-a","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Pain at injection site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"By blocking acetylcholine release, intra-articular botulinum toxin type A reduces muscle spasms and inflammation in joints, providing pain relief and improving joint mobility. This mechanism is particularly effective in treating conditions characterized by excessive muscle contraction, such as arthritis and joint pain.","oneSentence":"Intra-articular botulinum toxin type A works by inhibiting the release of acetylcholine, a neurotransmitter that causes muscle contraction.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:48:39.007Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of chronic low back pain"}]},"trialDetails":[{"nctId":"NCT07385742","phase":"NA","title":"Botulinum Toxin Versus Platelet Rich Fibrin for TMJ Internal Derangement","status":"COMPLETED","sponsor":"Suez Canal University","startDate":"2024-01-10","conditions":"Temporomandibular Joint Internal Derangement, Temporomandibular Joint Disorders, Temporomandibular Disorders (TMD)","enrollment":20},{"nctId":"NCT03726788","phase":"PHASE2","title":"Intra Articular Injection of Botulinum Toxin Versus Corticoids in Gonarthrosis","status":"WITHDRAWN","sponsor":"Lille Catholic University","startDate":"2019-09","conditions":"Joint Diseases, Knee, Therapeutics","enrollment":""},{"nctId":"NCT03187626","phase":"PHASE2, PHASE3","title":"Efficacy of an Intra-articular Injection of Botulinum Toxin A Associated With Splinting for Base-of-thumb Osteoarthritis","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2018-11-29","conditions":"Base-of-thumb Osteoarthritis","enrollment":60},{"nctId":"NCT06902805","phase":"PHASE2, PHASE3","title":"Efficacy of Two Ultrasound-guided Intra-articular Injections of Botox® Combined With Custom-made Rigid Splinting in Painful Base-of-thumb Osteoarthritis.","status":"NOT_YET_RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2025-05","conditions":"Base-of-thumb Osteoarthritis, Osteoarthritis","enrollment":120},{"nctId":"NCT06207955","phase":"NA","title":"I-PRF After Arthrocentesis Plus Botox Injection to Lateral Pterygoid Muscle in Treatment of Anterior Disc Displacement","status":"UNKNOWN","sponsor":"Fayoum University","startDate":"2024-02","conditions":"TMJ Disc Disorder, TMJ Pain","enrollment":39},{"nctId":"NCT02832713","phase":"PHASE2","title":"Trial Comparing Botulin Toxin Versus Hyaluronic Acid by Intra-articular Injection for the Treatment of Painful Knee Osteoarthritis","status":"UNKNOWN","sponsor":"University Hospital, Strasbourg, France","startDate":"2017-06-09","conditions":"Painful Unilateral Femorotibial Knee Osteoarthritis of Any Etiology","enrollment":50},{"nctId":"NCT00403273","phase":"PHASE2","title":"Safety and Efficacy of Botulinum Toxin A Injection in Patients With Painful Artificial Knee Arthroplasty (TKA)","status":"COMPLETED","sponsor":"Minneapolis Veterans Affairs Medical Center","startDate":"2006-07","conditions":"Knee Pain","enrollment":54},{"nctId":"NCT02230956","phase":"PHASE2","title":"BOTOX® Efficacy and Safety in the Treatment of Knee Osteoarthritis","status":"COMPLETED","sponsor":"Allergan","startDate":"2014-10","conditions":"Osteoarthritis","enrollment":176},{"nctId":"NCT02829281","phase":"PHASE4","title":"Intra-articular Botox Type A Versus Corticosteroids in Knee Osteoarthritis","status":"UNKNOWN","sponsor":"Federal University of São Paulo","startDate":"2016-07","conditions":"Knee Osteoarthritis","enrollment":105},{"nctId":"NCT01518257","phase":"PHASE1, PHASE2","title":"Safety and Efficacy Study of Botulinum Toxin Type A as Treatment for Osteoarthritis Knee Pain","status":"COMPLETED","sponsor":"Allergan","startDate":"2012-01","conditions":"Osteoarthritis","enrollment":121},{"nctId":"NCT01760577","phase":"NA","title":"Effects of Intraarticular Botulinum Toxin A in Ankle Osteoarthritis","status":"COMPLETED","sponsor":"Kaohsiung Veterans General Hospital.","startDate":"2010-05","conditions":"Ankle Osteoarthritis","enrollment":70},{"nctId":"NCT00279903","phase":"PHASE1","title":"Is Botox Effective in Relieving Pain From Knee Osteoarthritis?","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2005-11","conditions":"Osteoarthritis, Knee","enrollment":62},{"nctId":"NCT01473277","phase":"PHASE2","title":"Botulinum Toxin Type A (BT-A) in Hemiplegic Shoulder Pain Versus Steroid","status":"UNKNOWN","sponsor":"The Foundation Institute San Raffaele G. Giglio of Cefalù","startDate":"2012-01","conditions":"Stroke, Hemiparesis, Shoulder Pain","enrollment":52},{"nctId":"NCT00211718","phase":"PHASE3","title":"Intra-Articular Injection of Botulinum Toxin Type A for Shoulder Pain","status":"UNKNOWN","sponsor":"Minneapolis Veterans Affairs Medical Center","startDate":"2004-07","conditions":"Arthritis, Shoulder Pain","enrollment":40},{"nctId":"NCT00211679","phase":"PHASE2","title":"Intra-articularInjection of Botulinum Toxin Type","status":"UNKNOWN","sponsor":"Minneapolis Veterans Affairs Medical Center","startDate":"2004-06","conditions":"Arthritis, Pain","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":9,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"intra-articular botulinum toxin type a","genericName":"intra-articular botulinum toxin type a","companyName":"Minneapolis Veterans Affairs Medical Center","companyId":"minneapolis-veterans-affairs-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Intra-articular botulinum toxin type A works by inhibiting the release of acetylcholine, a neurotransmitter that causes muscle contraction. Used for Treatment of chronic low back pain.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}