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Intra-arterial infusion of Alteplase
Intra-arterial infusion of Alteplase is a Fibrinolytic agent / Tissue plasminogen activator (tPA) Small molecule drug developed by Central Hospital, Nancy, France. It is currently in Phase 3 development for Acute ischemic stroke (intra-arterial thrombolysis), Acute arterial thrombosis, Peripheral arterial occlusion.
Alteplase is a tissue plasminogen activator (tPA) that converts plasminogen to plasmin, directly dissolving fibrin clots when delivered intra-arterially.
Alteplase is a tissue plasminogen activator (tPA) that converts plasminogen to plasmin, directly dissolving fibrin clots when delivered intra-arterially. Used for Acute ischemic stroke (intra-arterial thrombolysis), Acute arterial thrombosis, Peripheral arterial occlusion.
At a glance
| Generic name | Intra-arterial infusion of Alteplase |
|---|---|
| Sponsor | Central Hospital, Nancy, France |
| Drug class | Fibrinolytic agent / Tissue plasminogen activator (tPA) |
| Target | Plasminogen / Fibrin |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 3 |
Mechanism of action
Alteplase binds to fibrin in thrombi and catalyzes the conversion of plasminogen to plasmin, which degrades the fibrin matrix of blood clots. When administered via intra-arterial infusion, it achieves high local concentrations at the site of thrombosis, enabling rapid clot lysis with potentially reduced systemic fibrinolytic effects compared to intravenous administration.
Approved indications
- Acute ischemic stroke (intra-arterial thrombolysis)
- Acute arterial thrombosis
- Peripheral arterial occlusion
Common side effects
- Intracranial hemorrhage
- Systemic bleeding
- Reperfusion injury
- Allergic reaction
Key clinical trials
- Reperfusion Completion Via Local Arterial Infusion of Tenecteplase After Incomplete Mechanical Thrombectomy (PHASE3)
- Evaluate the Safety and Explore Efficacy of Umbilical Cord Mesenchymal Stem Cells in Acute Ischemic Stroke (PHASE1)
- Testosterone Deficiency and Endothelial Dysfunction After Spinal Cord Injury
- CHemical OptImization of Cerebral Embolectomy 2 (CHOICE 2). (PHASE3)
- Intra-Arterial Thrombolysis After SUCCESSful Reperfusion in Anterior Circulation Ischemic Stroke (PHASE3)
- Intra-arterial Hypothermic Magnesium Sulfate Infusion in Combination with Endovascular Thrombectomy in Acute Ischemic Stroke (EARLY_PHASE1)
- Intra-arterial Alteplase for Acute Ischemic Stroke After Mechanical Thrombectomy (PHASE3)
- Patient Selection Using MR With Non-Perfusion Imaging for Endovascular Treatment Within 6 to 24 Hours (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Intra-arterial infusion of Alteplase CI brief — competitive landscape report
- Intra-arterial infusion of Alteplase updates RSS · CI watch RSS
- Central Hospital, Nancy, France portfolio CI
Frequently asked questions about Intra-arterial infusion of Alteplase
What is Intra-arterial infusion of Alteplase?
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Related
- Drug class: All Fibrinolytic agent / Tissue plasminogen activator (tPA) drugs
- Target: All drugs targeting Plasminogen / Fibrin
- Manufacturer: Central Hospital, Nancy, France — full pipeline
- Therapeutic area: All drugs in Cardiovascular
- Indication: Drugs for Acute ischemic stroke (intra-arterial thrombolysis)
- Indication: Drugs for Acute arterial thrombosis
- Indication: Drugs for Peripheral arterial occlusion
- Compare: Intra-arterial infusion of Alteplase vs similar drugs
- Pricing: Intra-arterial infusion of Alteplase cost, discount & access