{"id":"intra-arterial-infusion-of-alteplase","safety":{"commonSideEffects":[{"rate":null,"effect":"Intracranial hemorrhage"},{"rate":null,"effect":"Systemic bleeding"},{"rate":null,"effect":"Reperfusion injury"},{"rate":null,"effect":"Allergic reaction"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Alteplase binds to fibrin in thrombi and catalyzes the conversion of plasminogen to plasmin, which degrades the fibrin matrix of blood clots. When administered via intra-arterial infusion, it achieves high local concentrations at the site of thrombosis, enabling rapid clot lysis with potentially reduced systemic fibrinolytic effects compared to intravenous administration.","oneSentence":"Alteplase is a tissue plasminogen activator (tPA) that converts plasminogen to plasmin, directly dissolving fibrin clots when delivered intra-arterially.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:16:35.178Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute ischemic stroke (intra-arterial thrombolysis)"},{"name":"Acute arterial thrombosis"},{"name":"Peripheral arterial occlusion"}]},"trialDetails":[{"nctId":"NCT07471282","phase":"PHASE3","title":"Reperfusion Completion Via Local Arterial Infusion of Tenecteplase After Incomplete Mechanical Thrombectomy","status":"NOT_YET_RECRUITING","sponsor":"Chuansheng Zhao","startDate":"2026-03-01","conditions":"Stroke","enrollment":344},{"nctId":"NCT04434768","phase":"PHASE1","title":"Evaluate the Safety and Explore Efficacy of Umbilical Cord Mesenchymal Stem Cells in Acute Ischemic Stroke","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ever Supreme Bio Technology Co., Ltd.","startDate":"2020-12-02","conditions":"Acute Stroke","enrollment":10},{"nctId":"NCT07227740","phase":"","title":"Testosterone Deficiency and Endothelial Dysfunction After Spinal Cord Injury","status":"RECRUITING","sponsor":"Craig Hospital","startDate":"2025-07-15","conditions":"Spinal Cord Injuries, Endothelial Dysfunction, Testosterone Deficiency","enrollment":48},{"nctId":"NCT05797792","phase":"PHASE3","title":"CHemical OptImization of Cerebral Embolectomy 2 (CHOICE 2).","status":"ACTIVE_NOT_RECRUITING","sponsor":"Hospital Clinic of Barcelona","startDate":"2023-11-18","conditions":"Stroke, Acute Ischemic, Stroke, Acute","enrollment":440},{"nctId":"NCT06768138","phase":"PHASE3","title":"Intra-Arterial Thrombolysis After SUCCESSful Reperfusion in Anterior Circulation Ischemic Stroke","status":"RECRUITING","sponsor":"Central Hospital, Nancy, France","startDate":"2025-06-01","conditions":"Stroke, Acute Ischemic","enrollment":626},{"nctId":"NCT06760195","phase":"EARLY_PHASE1","title":"Intra-arterial Hypothermic Magnesium Sulfate Infusion in Combination with Endovascular Thrombectomy in Acute Ischemic Stroke","status":"NOT_YET_RECRUITING","sponsor":"Capital Medical University","startDate":"2025-01-10","conditions":"Acute Ischemic Stroke","enrollment":6},{"nctId":"NCT05856851","phase":"PHASE3","title":"Intra-arterial Alteplase for Acute Ischemic Stroke After Mechanical Thrombectomy","status":"RECRUITING","sponsor":"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University","startDate":"2023-08-01","conditions":"Stroke, Acute Ischemic","enrollment":324},{"nctId":"NCT05735301","phase":"NA","title":"Patient Selection Using MR With Non-Perfusion Imaging for Endovascular Treatment Within 6 to 24 Hours","status":"RECRUITING","sponsor":"Tianjin Huanhu Hospital","startDate":"2019-01-01","conditions":"Endovascular Thrombectomy","enrollment":352},{"nctId":"NCT01096693","phase":"NA","title":"Effects of Urocortins on Forearm Arterial Blood Flow in Healthy Volunteers (Protocol 2)","status":"COMPLETED","sponsor":"University of Edinburgh","startDate":"2010-08","conditions":"Vascular Disease, Heart Disease","enrollment":12},{"nctId":"NCT05684172","phase":"PHASE2, PHASE3","title":"Intra-arterial TNK Following Endovascular Thrombectomy in Patients With Large Vessel Occlusion of Posterior Circulation","status":"COMPLETED","sponsor":"The First Affiliated Hospital of University of Science and Technology of China","startDate":"2023-01-24","conditions":"Acute Ischemic Stroke, Intracranial Artery Occlusion, Endovascular Thrombectomy","enrollment":208},{"nctId":"NCT05624190","phase":"PHASE4","title":"Intra-arterial Recombinant Human TNK Tissue-type Plasminogen Activator (rhTNK-tPA) Thrombolysis for Acute Large Vascular Occlusion After Successful Mechanical Thrombectomy Recanalization","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2023-02-16","conditions":"Ischemic Stroke, Acute","enrollment":256},{"nctId":"NCT05580822","phase":"PHASE2","title":"Additive Effects of Intra-arterial Tenecteplase for Successful Thrombectomy Due to Acute Basilar Artery Occlusion","status":"UNKNOWN","sponsor":"First Hospital of China Medical University","startDate":"2023-01-01","conditions":"Basilar Artery Occlusion, Thrombectomy, Tenecteplase","enrollment":520},{"nctId":"NCT03876119","phase":"PHASE2, PHASE3","title":"Intraarterial Alteplase Versus Placebo After Mechanical Thrombectomy","status":"COMPLETED","sponsor":"Hospital Clinic of Barcelona","startDate":"2018-12-05","conditions":"Stroke, Acute","enrollment":121},{"nctId":"NCT02448069","phase":"PHASE2","title":"Safety and Feasibility of Argatroban, Tissue Plasminogen Activator and Intra-arterial Therapy in Stroke","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2015-05","conditions":"Stroke, Cerebral Ischemia","enrollment":10},{"nctId":"NCT01222117","phase":"PHASE2","title":"A Study of Intra-thrombus Plasmin (Human) In Acute Peripheral Arterial Occlusion","status":"COMPLETED","sponsor":"Grifols Therapeutics LLC","startDate":"2010-12","conditions":"Acute Peripheral Arterial Occlusion","enrollment":174},{"nctId":"NCT01413542","phase":"NA","title":"Pharmacogenetics of Ace Inhibitor-Associated Angioedema","status":"COMPLETED","sponsor":"Vanderbilt University","startDate":"2011-11","conditions":"Hypertension, Diabetes Type 2","enrollment":44},{"nctId":"NCT00359424","phase":"PHASE3","title":"Interventional Management of Stroke (IMS) III Trial","status":"TERMINATED","sponsor":"Joseph Broderick","startDate":"2006-08","conditions":"Stroke","enrollment":656},{"nctId":"NCT01599728","phase":"NA","title":"Effect of Urocortins in Patients With Heart Failure","status":"COMPLETED","sponsor":"University of Edinburgh","startDate":"2012-05","conditions":"Heart Failure, Endothelium","enrollment":22},{"nctId":"NCT00685945","phase":"NA","title":"Renin-Angiotensin Aldosterone System and Fibrinolysis Interaction in Humans-Specific Aim 3","status":"COMPLETED","sponsor":"Vanderbilt University","startDate":"2007-12","conditions":"Obesity","enrollment":24},{"nctId":"NCT00540527","phase":"PHASE3","title":"Local Versus Systemic Thrombolysis for Acute Ischemic Stroke (SYNTHESIS)","status":"COMPLETED","sponsor":"Niguarda Hospital","startDate":"2004-01","conditions":"Stroke, Cerebrovascular Accident","enrollment":54},{"nctId":"NCT01096706","phase":"NA","title":"Effects of Urocortins on Forearm Arterial Blood Flow in Healthy Volunteers (Protocol 3)","status":"COMPLETED","sponsor":"University of Edinburgh","startDate":"2011-07","conditions":"Vascular Disease, Heart Disease","enrollment":10},{"nctId":"NCT01455935","phase":"PHASE2","title":"Wake up Symptomatic Stroke - Benefit of Intravenous Clot Busters or Endovascular Intervention","status":"UNKNOWN","sponsor":"Jacobs Neurological Institute","startDate":"2011-11","conditions":"Stroke","enrollment":90}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":59,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Intra-arterial infusion of Alteplase","genericName":"Intra-arterial infusion of Alteplase","companyName":"Central Hospital, Nancy, France","companyId":"central-hospital-nancy-france","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Alteplase is a tissue plasminogen activator (tPA) that converts plasminogen to plasmin, directly dissolving fibrin clots when delivered intra-arterially. Used for Acute ischemic stroke (intra-arterial thrombolysis), Acute arterial thrombosis, Peripheral arterial occlusion.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}