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Intra-arterial Alteplase for Acute Ischemic Stroke After Mechanical Thrombectomy (PEARL): A Multicenter, Prospective, Open-label, Blinded Endpoint, Randomized Controlled Trial
A multicenter, prospective, open-label, blinded endpoint, randomized controlled trial aiming at evaluating the efficacy and safety of intra-arterial recombinant human tissue plasminogen activator (rt-PA) after successful recanalization of acute large vessel occlusion in the anterior circulation by mechanical thrombectomy in improving the 90-day functional outcome.
Details
| Lead sponsor | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University |
|---|---|
| Phase | Phase 3 |
| Status | RECRUITING |
| Enrolment | 324 |
| Start date | 2023-08-01 |
| Completion | 2025-12 |
Conditions
- Stroke, Acute Ischemic
Interventions
- Alteplase
Primary outcomes
- The modified Rankin Scale score (mRS) 0-1 — 90(±7) days
The proportion of the modified Rankin Scale score (mRS) 0-1 at 90 days.
Countries
China