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Injection, botulinum toxin + corticoid
Botulinum toxin blocks acetylcholine release at the neuromuscular junction to reduce muscle contractions, while the corticoid provides anti-inflammatory effects.
Botulinum toxin blocks acetylcholine release at the neuromuscular junction to reduce muscle contractions, while the corticoid provides anti-inflammatory effects. Used for Spasticity or muscle hyperactivity disorders (investigational combination), Chronic pain conditions with muscular component (investigational).
At a glance
| Generic name | Injection, botulinum toxin + corticoid |
|---|---|
| Sponsor | Assistance Publique - Hôpitaux de Paris |
| Drug class | Neurotoxin + corticosteroid combination |
| Target | Acetylcholine release machinery (SNARE complex); glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Neurology / Dermatology / Pain Management |
| Phase | Phase 3 |
Mechanism of action
Botulinum toxin irreversibly inhibits acetylcholine release by cleaving SNARE proteins, causing temporary muscle paralysis. The co-formulated corticoid reduces local inflammation and may enhance therapeutic efficacy or reduce immune responses to the toxin. This combination targets both neuromuscular and inflammatory pathways in the injection site.
Approved indications
- Spasticity or muscle hyperactivity disorders (investigational combination)
- Chronic pain conditions with muscular component (investigational)
Common side effects
- Muscle weakness or paralysis at injection site
- Pain or bruising at injection site
- Systemic corticoid effects (with repeated dosing)
- Antibody formation to botulinum toxin
Key clinical trials
- Silencing Neuroma Pain-Botulinum Toxin Versus Local Anesthetic Injection (NA)
- Evaluation of Three Types of Injection for the Treatment of Lateral Epicondylalgia (NA)
- Intra Articular Injection of Botulinum Toxin Versus Corticoids in Gonarthrosis (PHASE2)
- Clinical Effects of Incobotulinum Toxin vs Corticosteroid in Plantar Fascitis (PHASE1)
- Injection of Botulinum Toxin for Thumb Carpometacarpal Arthritis (PHASE3)
- Efficacy of Nerve Block Versus Botox in Chronic Migraine Management (NA)
- A Phase III Study to Evaluate Efficacy of Botulinum Toxin for Treating Epicondylitis (PHASE3)
- Ultrasound Guided Botulinum Toxin Type A Injection of Subacromial-Subdeltoid Bursa in Hemiplegic Shoulder Pain (EARLY_PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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