{"id":"injection-botulinum-toxin-corticoid","safety":{"commonSideEffects":[{"rate":null,"effect":"Muscle weakness or paralysis at injection site"},{"rate":null,"effect":"Pain or bruising at injection site"},{"rate":null,"effect":"Systemic corticoid effects (with repeated dosing)"},{"rate":null,"effect":"Antibody formation to botulinum toxin"}]},"_chembl":{"chemblId":"CHEMBL4297862","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Botulinum toxin irreversibly inhibits acetylcholine release by cleaving SNARE proteins, causing temporary muscle paralysis. The co-formulated corticoid reduces local inflammation and may enhance therapeutic efficacy or reduce immune responses to the toxin. This combination targets both neuromuscular and inflammatory pathways in the injection site.","oneSentence":"Botulinum toxin blocks acetylcholine release at the neuromuscular junction to reduce muscle contractions, while the corticoid provides anti-inflammatory effects.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:16:14.327Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Spasticity or muscle hyperactivity disorders (investigational combination)"},{"name":"Chronic pain conditions with muscular component (investigational)"}]},"trialDetails":[{"nctId":"NCT07431944","phase":"NA","title":"Silencing Neuroma Pain-Botulinum Toxin Versus Local Anesthetic Injection","status":"NOT_YET_RECRUITING","sponsor":"Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)","startDate":"2026-02-15","conditions":"Pain Management, Pain, Phantom Limb Pain","enrollment":100},{"nctId":"NCT02325063","phase":"NA","title":"Evaluation of Three Types of Injection for the Treatment of Lateral Epicondylalgia","status":"TERMINATED","sponsor":"Centre Hospitalier Universitaire de Nīmes","startDate":"2015-12-17","conditions":"Epicondylitis, Lateral Humeral, Tennis Elbow","enrollment":13},{"nctId":"NCT03726788","phase":"PHASE2","title":"Intra Articular Injection of Botulinum Toxin Versus Corticoids in Gonarthrosis","status":"WITHDRAWN","sponsor":"Lille Catholic University","startDate":"2019-09","conditions":"Joint Diseases, Knee, Therapeutics","enrollment":""},{"nctId":"NCT06788158","phase":"PHASE1","title":"Clinical Effects of Incobotulinum Toxin vs Corticosteroid in Plantar Fascitis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Instituto Mexicano del Seguro Social","startDate":"2024-09-01","conditions":"Plantar Fasciitis of Both Feet, Pain, Function","enrollment":20},{"nctId":"NCT05990881","phase":"PHASE3","title":"Injection of Botulinum Toxin for Thumb Carpometacarpal Arthritis","status":"RECRUITING","sponsor":"Rhode Island Hospital","startDate":"2023-08-27","conditions":"Carpometacarpal Sprain, Thumb Sprain, Clostridium; Botulinum","enrollment":50},{"nctId":"NCT06684249","phase":"NA","title":"Efficacy of Nerve Block Versus Botox in Chronic Migraine Management","status":"RECRUITING","sponsor":"Zagazig University","startDate":"2024-11-10","conditions":"Chronic Migraine, Chronic Migraine, Headache","enrollment":64},{"nctId":"NCT03380559","phase":"PHASE3","title":"A Phase III Study to Evaluate Efficacy of Botulinum Toxin for Treating Epicondylitis","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2019-04-19","conditions":"Epicondylitis","enrollment":33},{"nctId":"NCT04467450","phase":"EARLY_PHASE1","title":"Ultrasound Guided Botulinum Toxin Type A Injection of Subacromial-Subdeltoid Bursa in Hemiplegic Shoulder Pain","status":"UNKNOWN","sponsor":"Benha University","startDate":"2020-06-01","conditions":"Subacromial Bursitis, Subdeltoid Bursitis","enrollment":36},{"nctId":"NCT00701233","phase":"PHASE2","title":"Botulinum Toxin for Carpal Tunnel Syndrome","status":"WITHDRAWN","sponsor":"University of Minnesota","startDate":"2012-06","conditions":"Carpal Tunnel Syndrome","enrollment":""},{"nctId":"NCT02829281","phase":"PHASE4","title":"Intra-articular Botox Type A Versus Corticosteroids in Knee Osteoarthritis","status":"UNKNOWN","sponsor":"Federal University of São Paulo","startDate":"2016-07","conditions":"Knee Osteoarthritis","enrollment":105},{"nctId":"NCT00999869","phase":"NA","title":"The Comparison Study of Intralesional Botulinum Toxin A and Corticosteroid Injection for Alopecia Areata","status":"UNKNOWN","sponsor":"Siriraj Hospital","startDate":"2009-11","conditions":"Alopecia Areata","enrollment":20},{"nctId":"NCT00395616","phase":"NA","title":"Comparison Between Type A Botulinum Toxin Injection and Corticosteroid Injection in the Treatment of Tennis Elbow","status":"UNKNOWN","sponsor":"E-DA Hospital","startDate":"2006-11","conditions":"Type A Botulinum Toxin, Tennis Elbow","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Injection, botulinum toxin + corticoid","genericName":"Injection, botulinum toxin + corticoid","companyName":"Assistance Publique - Hôpitaux de Paris","companyId":"assistance-publique-h-pitaux-de-paris","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Botulinum toxin blocks acetylcholine release at the neuromuscular junction to reduce muscle contractions, while the corticoid provides anti-inflammatory effects. Used for Spasticity or muscle hyperactivity disorders (investigational combination), Chronic pain conditions with muscular component (investigational).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}