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NCT06684249
Efficacy of Nerve Block Versus Botox in Chronic Migraine Management
NA trial testing Nerve Block Injections in Chronic Migraine in 64 participants. Currently enrolling.
10 May 2025
Quick facts
| Lead sponsor | Zagazig University |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 64 |
| Start date | 10 November 2024 |
| Primary completion | 10 May 2025 |
| Estimated completion | 10 July 2025 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Nerve Block Injections
- Botulinum Toxin A — full drug profile →
Conditions studied
- Chronic Migraine — all drugs for Chronic Migraine →
- Chronic Migraine, Headache — all drugs for Chronic Migraine, Headache →
Sponsor
Zagazig University
Who can join
Adults 18 to 65, any sex, with Chronic Migraine or Chronic Migraine, Headache. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial is to determine whether nerve block injections (specifically, supratrochlear and greater occipital nerve injections) are as effective as Botulinum toxin A (Botox) injections in treating chronic migraine in adults. The main questions it aims to answer are: * Do nerve block injections reduce the number of monthly migraine days compared to baseline? * Are there any differences in the frequency of migraine-related symptoms between the nerve block and Botox treatment groups? * Which treatment leads to higher patient satisfaction and improved quality of life? Participants in this study will: * Receive either nerve block injections or Botox injections every 12 weeks. * Visit the clinic once every month for follow-ups and assessments. * Maintain a headache diary to record the frequency and severity of their migraines and any adverse effects experienced. * Researchers will compare the outcomes of the two groups to determine if one treatment is superior in terms of efficacy and patient satisfaction.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Uses of Botulinum Toxin in Headache and Facial Pain Disorders: An Update.
Sampaio Rocha-Filho PA, Dominguez M, Robinson CL, Ashina S. · · 2025 · PMID 40711126 · DOI 10.3390/toxins17070314
Verify or expand the search:
- PubMed search for NCT06684249
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Chronic Migraine
Currently open trials in the same condition.
- NCT06974617 — Sphenopalatine Block Versus BOTOX in Management of Chronic Migraine · NA · recruiting
- NCT05337033 — Cannabis for Chronic Headaches in Adolescents: the CAN-CHA Trial · Phase 2 · recruiting
- NCT06625060 — A Study to Evaluate IPN10200 Safety and Efficacy in the Prevention of Episodic or Chronic Migraine in Adults · Phase 2 · recruiting
- NCT06450444 — The RECLAIM Study. · NA · recruiting
- NCT06322407 — Ultrasound-guided Stellate Ganglion Block for Treatment of Chronic Migraine in Adult · NA · recruiting
Other Zagazig University trials
Trials by the same sponsor.
- NCT07423676 — Comparison Between Two Drugs in Sedation of Upper GI Endoscopy · not yet recruiting
- NCT07418307 — Comparison Between Combined Biceps Femoris Short Head Block and Adductor Canal Block Versus Genicular Nerve Block · NA · not yet recruiting
- NCT07435025 — Surgery for Obstructed Gastric Carcinoma · NA · active not recruiting
- NCT07330375 — Effect of Intravenous Dexmedetomidine and Ketamine on Post-Operative Analgesia · Phase 3 · not yet recruiting
- NCT07309731 — Impact OF Cooled Versus Thermal Radiofrequency Denervation In Management Of Chronic Lumber Facet Joint Pain · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06684249 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Zagazig University
- Last refreshed: 12 November 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06684249.
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