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Essential oils without alcohol
Essential oils without alcohol is a Small molecule drug developed by University of Santiago de Compostela. It is currently FDA-approved for Topical antimicrobial or anti-inflammatory applications, Aromatherapy and wellness support. Also known as: Listerine Zero.
Essential oils without alcohol deliver volatile plant compounds through topical or inhalation routes to provide therapeutic effects such as antimicrobial, anti-inflammatory, or aromatic benefits.
Essential oils without alcohol are being studied for their antibacterial effects against oral biofilm, dental plaque, periodontitis, gingivitis, and plaque. As small molecules with an unknown mechanism of action, essential oils without alcohol have been investigated in clinical trials for their substantivity and anti-plaque effects.
At a glance
| Generic name | Essential oils without alcohol |
|---|---|
| Also known as | Listerine Zero |
| Sponsor | University of Santiago de Compostela |
| Modality | Small molecule |
| Therapeutic area | Dermatology, Aromatherapy, Complementary Medicine |
| Phase | FDA-approved |
Mechanism of action
Essential oils are concentrated plant extracts containing bioactive compounds (terpenes, phenols, esters) that exert pharmacological effects when applied to skin or inhaled. Without alcohol as a carrier or preservative, these formulations rely on the intrinsic properties of the oils themselves. The mechanism varies by oil composition and therapeutic application, ranging from direct antimicrobial activity to modulation of inflammatory pathways or sensory nerve stimulation.
Approved indications
- Topical antimicrobial or anti-inflammatory applications
- Aromatherapy and wellness support
Common side effects
- Skin irritation or sensitization
- Allergic contact dermatitis
- Photosensitivity (with certain oils)
Key clinical trials
- Olfactory Performance in Culinary Arts Students (PHASE4)
- Clinical Effectiveness of 5 Different Mouthwashes in the Treatment of Generalised Gingivitis (NA)
- Essential Oils With and Without Alcohol: Substantivity and Antiplaque Effect (PHASE4)
- Antiplaque/Antigingivitis Efficacy of Essential Oil Mouthrinses in Six-Month Study (NA)
- Antiplaque Effect of Essential Oils With and Without Alcochol on an in Situ Model of Oral Biofilm Growth (PHASE4)
- Immediate Effect and Substantivity of the Essential Oils Without Alcohol on the Oral Biofilm in Situ (PHASE4)
- Essential Oil+ELA, Plaque and Gingivitis (PHASE4)
- Efficacy of Essential Oil Mouthwash With and Without Alcohol: a 3-Day Plaque Accumulation Model (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Essential oils without alcohol CI brief — competitive landscape report
- Essential oils without alcohol updates RSS · CI watch RSS
- University of Santiago de Compostela portfolio CI
Frequently asked questions about Essential oils without alcohol
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Related
- Manufacturer: University of Santiago de Compostela — full pipeline
- Therapeutic area: All drugs in Dermatology, Aromatherapy, Complementary Medicine
- Indication: Drugs for Topical antimicrobial or anti-inflammatory applications
- Indication: Drugs for Aromatherapy and wellness support
- Also known as: Listerine Zero
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing