{"id":"essential-oils-without-alcohol","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation or sensitization"},{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Photosensitivity (with certain oils)"}]},"_chembl":{"chemblId":"CHEMBL720","moleculeType":"Small molecule","molecularWeight":"108.14"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Essential oils are concentrated plant extracts containing bioactive compounds (terpenes, phenols, esters) that exert pharmacological effects when applied to skin or inhaled. Without alcohol as a carrier or preservative, these formulations rely on the intrinsic properties of the oils themselves. The mechanism varies by oil composition and therapeutic application, ranging from direct antimicrobial activity to modulation of inflammatory pathways or sensory nerve stimulation.","oneSentence":"Essential oils without alcohol deliver volatile plant compounds through topical or inhalation routes to provide therapeutic effects such as antimicrobial, anti-inflammatory, or aromatic benefits.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:39:20.646Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical antimicrobial or anti-inflammatory applications"},{"name":"Aromatherapy and wellness support"}]},"trialDetails":[{"nctId":"NCT06066307","phase":"PHASE4","title":"Olfactory Performance in Culinary Arts Students","status":"UNKNOWN","sponsor":"Leigh Sowerby","startDate":"2023-09-25","conditions":"Loss of Smell, Olfactory Disorder","enrollment":120},{"nctId":"NCT04733196","phase":"NA","title":"Clinical Effectiveness of 5 Different Mouthwashes in the Treatment of Generalised Gingivitis","status":"COMPLETED","sponsor":"Plovdiv Medical University","startDate":"2020-10-01","conditions":"Gingivitis","enrollment":180},{"nctId":"NCT03146390","phase":"PHASE4","title":"Essential Oils With and Without Alcohol: Substantivity and Antiplaque Effect","status":"UNKNOWN","sponsor":"University of Santiago de Compostela","startDate":"2017-05-02","conditions":"Oral Biofilm, Dental Plaque, Periodontitis","enrollment":20},{"nctId":"NCT02980497","phase":"NA","title":"Antiplaque/Antigingivitis Efficacy of Essential Oil Mouthrinses in Six-Month Study","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer and Personal Products Worldwide","startDate":"2013-09","conditions":"Plaque, Gingivitis, Gum Inflammation","enrollment":370},{"nctId":"NCT02946801","phase":"PHASE4","title":"Antiplaque Effect of Essential Oils With and Without Alcochol on an in Situ Model of Oral Biofilm Growth","status":"UNKNOWN","sponsor":"University of Santiago de Compostela","startDate":"2016-11","conditions":"Biofilms, Oils, Essential, Periodontitis","enrollment":20},{"nctId":"NCT02946814","phase":"PHASE4","title":"Immediate Effect and Substantivity of the Essential Oils Without Alcohol on the Oral Biofilm in Situ","status":"UNKNOWN","sponsor":"University of Santiago de Compostela","startDate":"2016-10","conditions":"Biofilms, Substantivity, Oils, Essential","enrollment":20},{"nctId":"NCT02884817","phase":"PHASE4","title":"Essential Oil+ELA, Plaque and Gingivitis","status":"COMPLETED","sponsor":"University of Oslo","startDate":"2015-09","conditions":"Dental Plaque, Gingivitis","enrollment":59},{"nctId":"NCT01411618","phase":"NA","title":"Efficacy of Essential Oil Mouthwash With and Without Alcohol: a 3-Day Plaque Accumulation Model","status":"COMPLETED","sponsor":"University of L'Aquila","startDate":"2010-06","conditions":"Gingivitis, Periodontitis","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Listerine Zero"],"phase":"marketed","status":"active","brandName":"Essential oils without alcohol","genericName":"Essential oils without alcohol","companyName":"University of Santiago de Compostela","companyId":"university-of-santiago-de-compostela","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Essential oils without alcohol are being studied for their antibacterial effects against oral biofilm, dental plaque, periodontitis, gingivitis, and plaque. As small molecules with an unknown mechanism of action, essential oils without alcohol have been investigated in clinical trials for their substantivity and anti-plaque effects.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}