NCT02946814 is a Phase 4 clinical trial of essential oils in Biofilms, sponsored by University of Santiago de Compostela.

Who is sponsoring NCT02946814?

NCT02946814 is sponsored by University of Santiago de Compostela.

What drugs are being tested in NCT02946814?

Interventions in NCT02946814: essential oils, essential oils without mouthwash, sterile water.

What condition does NCT02946814 study?

NCT02946814 studies Biofilms, Substantivity, Oils, Essential.

Is NCT02946814 still recruiting?

NCT02946814 is currently status unknown. Last updated 25 October 2016.

Last reviewed 2016-10-25 · How we verify

NCT02946814

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Immediate Effect and Substantivity of the Essential Oils Without Alcohol on the Oral Biofilm in Situ. A Randomized Clinical Trial

Status unknown Phase 4 Last updated 25 October 2016

What this trial tests

Phase 4 trial testing essential oils in Biofilms in 20 participants. Status unknown.

Timeline

1 October 2016

Primary endpoint
1 November 2016

Quick facts

Lead sponsor	University of Santiago de Compostela
Phase	Phase 4
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	prevention
Enrollment	20
Start date	1 October 2016
Primary completion	1 November 2016

Drugs / interventions tested

essential oils — full drug profile →
essential oils without mouthwash — full drug profile →
sterile water (Sterile Water For Injection) — full drug profile →

Conditions studied

Biofilms — all drugs for Biofilms →
Substantivity — all drugs for Substantivity →
Oils, Essential — all drugs for Oils, Essential →

Sponsor

University of Santiago de Compostela

Who can join

18 and older, any sex, with Biofilms or Substantivity. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Percentage of bacterial viability
Time frame: 48 hours after the volunteer has started to wear the splints

Sponsor's own description

This study aims to evaluate the in situ antibacterial activity of a mouthwash containing essential oils with and without alcohol on undisturbed de novo plaque-like biofilm (PL-biofilm) up to 7 h after its application. An appliance was designed to hold six glass disks on the buccal sides of the lower teeth, allowing PL-biofilm growth. Twenty healthy volunteers will the appliance for 48 h and then performed a mouthwash with essential oils. Disks will be removed after 30 s and at 1, 3, 5, and 7 h later. After a washout period, the same procedure will be repeated with a sterile water mouthwash and a mouthwash with essential oils without alcohol. After PL-biofilm vital staining, samples will be analyzed using a confocal laser scanning microscope analysing their bacterial viability and thickness.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Screening strategies for quorum sensing inhibitors in combating bacterial infections.
Lu L, Li M, Yi G, Liao L, et al · · 2022 · cited 54× · PMID 35573879 · DOI 10.1016/j.jpha.2021.03.009

Verify or expand the search:

Other trials of essential oils

Trials testing the same drug.

NCT03662360 — Elderly Demented Patients: Aromatherapy Complementary to Psychopharmacotherapy Psychological Disorders and BPSD Behavior · NA · completed

Other recruiting trials for Biofilms

Currently open trials in the same condition.

NCT07228598 — Biofilm on Chest Drains After Thoracic Surgery: Clinical Impact and Antibiotic Resistance · recruiting

Other University of Santiago de Compostela trials

Trials by the same sponsor.

NCT07466004 — PERMA-Based Mobile Psychological Intervention With and Without Telephone Support for University Students · NA · not yet recruiting
NCT07343284 — Nursing Health Education to Improve Functionality and Quality of Life After Ischemic Stroke · NA · not yet recruiting
NCT07430748 — REGENFAST vs L-PRF in Periodontal Regeneration · EARLY_PHASE1 · active not recruiting
NCT07355673 — The Influence of Isolation Techniques in Gingival Irritation During an In-office Bleaching · NA · completed
NCT07355647 — Efficacy of a Desensitizing Agent During In-Office Bleaching · EARLY_PHASE1 · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02946814 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Santiago de Compostela
Last refreshed: 25 October 2016

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02946814.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing