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essential oils without mouthwash
Essential oils exert antimicrobial and anti-inflammatory effects in the oral cavity through volatile organic compounds that disrupt bacterial cell membranes and reduce inflammatory mediators.
Essential oils exert antimicrobial and anti-inflammatory effects in the oral cavity through volatile organic compounds that disrupt bacterial cell membranes and reduce inflammatory mediators. Used for Oral hygiene and antimicrobial activity, Plaque and gingivitis management.
At a glance
| Generic name | essential oils without mouthwash |
|---|---|
| Also known as | Listerine Zero |
| Sponsor | University of Santiago de Compostela |
| Modality | Small molecule |
| Therapeutic area | Oral Health / Dentistry |
| Phase | FDA-approved |
Mechanism of action
Essential oils contain bioactive compounds such as terpenes and phenols that demonstrate broad-spectrum antimicrobial activity against oral pathogens and can modulate inflammatory responses in oral tissues. When used without a mouthwash vehicle, the oils may be applied directly or in alternative formulations to provide oral hygiene and therapeutic benefits. The mechanism relies on the intrinsic properties of the oil constituents rather than a synthetic pharmaceutical target.
Approved indications
- Oral hygiene and antimicrobial activity
- Plaque and gingivitis management
Common side effects
- Oral irritation or mucosal sensitivity
- Allergic contact dermatitis
- Taste alteration
Key clinical trials
- The Antiplaque and Antigingivitis Effect of Pure Green Tea Mouth Wash Compared to Placebo and Essential Oils Mouth Washes (NA)
- Clinical Effectiveness of 5 Different Mouthwashes in the Treatment of Generalised Gingivitis (NA)
- Effect of Essential Oils as Adjutants on the Treatment of Subjects With Periodontitis: Assessment of Metabolic Variables as Effect Modifiers (NA)
- Povidone-Iodine Vs Essential Oil Vs Tap Water Gargling For COVID-19 Patients (PHASE2)
- Determination of the Safety and Efficacy of a Novel Oral Rinse on Oral Health (NA)
- Essential Oils With and Without Alcohol: Substantivity and Antiplaque Effect (PHASE4)
- Antiplaque/Antigingivitis Efficacy of Essential Oil Mouthrinses in Six-Month Study (NA)
- Antiplaque Effect of Essential Oils With and Without Alcochol on an in Situ Model of Oral Biofilm Growth (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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