{"id":"essential-oils-without-mouthwash","safety":{"commonSideEffects":[{"rate":null,"effect":"Oral irritation or mucosal sensitivity"},{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Taste alteration"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Essential oils contain bioactive compounds such as terpenes and phenols that demonstrate broad-spectrum antimicrobial activity against oral pathogens and can modulate inflammatory responses in oral tissues. When used without a mouthwash vehicle, the oils may be applied directly or in alternative formulations to provide oral hygiene and therapeutic benefits. The mechanism relies on the intrinsic properties of the oil constituents rather than a synthetic pharmaceutical target.","oneSentence":"Essential oils exert antimicrobial and anti-inflammatory effects in the oral cavity through volatile organic compounds that disrupt bacterial cell membranes and reduce inflammatory mediators.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:45:49.737Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Oral hygiene and antimicrobial activity"},{"name":"Plaque and gingivitis management"}]},"trialDetails":[{"nctId":"NCT07364565","phase":"NA","title":"The Antiplaque and Antigingivitis Effect of Pure Green Tea Mouth Wash Compared to Placebo and Essential Oils Mouth Washes","status":"RECRUITING","sponsor":"King Abdullah University Hospital","startDate":"2025-12-01","conditions":"Dental Plaque, Patient Reported Outcome, Gingival Inflammation and Bleeding","enrollment":44},{"nctId":"NCT04733196","phase":"NA","title":"Clinical Effectiveness of 5 Different Mouthwashes in the Treatment of Generalised Gingivitis","status":"COMPLETED","sponsor":"Plovdiv Medical University","startDate":"2020-10-01","conditions":"Gingivitis","enrollment":180},{"nctId":"NCT04692246","phase":"NA","title":"Effect of Essential Oils as Adjutants on the Treatment of Subjects With Periodontitis: Assessment of Metabolic Variables as Effect Modifiers","status":"TERMINATED","sponsor":"Universidad de Granada","startDate":"2019-11-01","conditions":"Periodontitis","enrollment":60},{"nctId":"NCT04410159","phase":"PHASE2","title":"Povidone-Iodine Vs Essential Oil Vs Tap Water Gargling For COVID-19 Patients","status":"COMPLETED","sponsor":"Universiti Sains Islam Malaysia","startDate":"2020-06-22","conditions":"COVID-19","enrollment":20},{"nctId":"NCT04197427","phase":"NA","title":"Determination of the Safety and Efficacy of a Novel Oral Rinse on Oral Health","status":"UNKNOWN","sponsor":"You First Services","startDate":"2020-03-01","conditions":"Plaque, Gingivitis","enrollment":62},{"nctId":"NCT03146390","phase":"PHASE4","title":"Essential Oils With and Without Alcohol: Substantivity and Antiplaque Effect","status":"UNKNOWN","sponsor":"University of Santiago de Compostela","startDate":"2017-05-02","conditions":"Oral Biofilm, Dental Plaque, Periodontitis","enrollment":20},{"nctId":"NCT02980497","phase":"NA","title":"Antiplaque/Antigingivitis Efficacy of Essential Oil Mouthrinses in Six-Month Study","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer and Personal Products Worldwide","startDate":"2013-09","conditions":"Plaque, Gingivitis, Gum Inflammation","enrollment":370},{"nctId":"NCT02946801","phase":"PHASE4","title":"Antiplaque Effect of Essential Oils With and Without Alcochol on an in Situ Model of Oral Biofilm Growth","status":"UNKNOWN","sponsor":"University of Santiago de Compostela","startDate":"2016-11","conditions":"Biofilms, Oils, Essential, Periodontitis","enrollment":20},{"nctId":"NCT02946814","phase":"PHASE4","title":"Immediate Effect and Substantivity of the Essential Oils Without Alcohol on the Oral Biofilm in Situ","status":"UNKNOWN","sponsor":"University of Santiago de Compostela","startDate":"2016-10","conditions":"Biofilms, Substantivity, Oils, Essential","enrollment":20},{"nctId":"NCT02884817","phase":"PHASE4","title":"Essential Oil+ELA, Plaque and Gingivitis","status":"COMPLETED","sponsor":"University of Oslo","startDate":"2015-09","conditions":"Dental Plaque, Gingivitis","enrollment":59},{"nctId":"NCT01411618","phase":"NA","title":"Efficacy of Essential Oil Mouthwash With and Without Alcohol: a 3-Day Plaque Accumulation Model","status":"COMPLETED","sponsor":"University of L'Aquila","startDate":"2010-06","conditions":"Gingivitis, Periodontitis","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":143,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Listerine Zero"],"phase":"marketed","status":"active","brandName":"essential oils without mouthwash","genericName":"essential oils without mouthwash","companyName":"University of Santiago de Compostela","companyId":"university-of-santiago-de-compostela","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Essential oils exert antimicrobial and anti-inflammatory effects in the oral cavity through volatile organic compounds that disrupt bacterial cell membranes and reduce inflammatory mediators. Used for Oral hygiene and antimicrobial activity, Plaque and gingivitis management.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}