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Epithelium-On Riboflavin
Epithelium-on riboflavin uses riboflavin (vitamin B2) with ultraviolet light exposure to strengthen corneal collagen cross-linking while preserving the corneal epithelium.
Epithelium-on riboflavin uses riboflavin (vitamin B2) with ultraviolet light exposure to strengthen corneal collagen cross-linking while preserving the corneal epithelium. Used for Corneal ectasia (keratoconus, post-refractive surgery ectasia), Corneal weakening and progressive myopia.
At a glance
| Generic name | Epithelium-On Riboflavin |
|---|---|
| Also known as | Vitamin B2 |
| Sponsor | Crowd Health Research, LTD |
| Drug class | Corneal cross-linking agent |
| Target | Corneal collagen (photochemical cross-linking via riboflavin and UVA) |
| Modality | Small molecule |
| Therapeutic area | Ophthalmology |
| Phase | Phase 3 |
Mechanism of action
This approach combines riboflavin photosensitization with UVA light to induce collagen cross-linking in the cornea, similar to standard corneal cross-linking (CXL) but maintains the corneal epithelium intact rather than removing it. By preserving the epithelial barrier, the technique aims to reduce postoperative pain, accelerate healing, and maintain corneal clarity while achieving biomechanical strengthening of the stroma.
Approved indications
- Corneal ectasia (keratoconus, post-refractive surgery ectasia)
- Corneal weakening and progressive myopia
Common side effects
- Corneal haze
- Transient epithelial edema
- Postoperative discomfort
- Refractive changes
Key clinical trials
- Epi-on CuRV and Epi-off aCXL Protocols in the Management of Keratoconus
- The Role of Adjuvant Corneal Crosslinking in the Management of Infective Keratitis (EARLY_PHASE1)
- Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age With Keratoconus (PHASE3)
- Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age with Keratoconus (PHASE3)
- Topo-Pachymetric Customized Accelerated Epi-On Vs Accelerated Epi-Off Corneal Cross Linking in Keratoconus Management (NA)
- Efficacy of Customized Corneal Cross-linking vs. Standard Corneal Cross-linking (NA)
- Corneal Collagen Crosslinking to Increase the Resistance of the Support Graft of the KPro Type I Against Corneal Melting (NA)
- Epithelium-on Cross-linking Versus Observation of Fellow Eyes of Patients With Unilateral Clinically Evident Keratoconus
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Epithelium-On Riboflavin CI brief — competitive landscape report
- Epithelium-On Riboflavin updates RSS · CI watch RSS
- Crowd Health Research, LTD portfolio CI