Who is sponsoring C-CROSS?

C-CROSS is sponsored by Maastricht University Medical Center.

What drugs are being tested in C-CROSS?

Interventions: Customized crosslinking, Standard crosslinking.

What is the status of C-CROSS?

C-CROSS is currently COMPLETED.

Last reviewed 2024-06-11 · How we verify

Efficacy of Customized Corneal Cross-linking vs. Standard Corneal Cross-linking (C-CROSS)

NCT04532788 NA COMPLETED

The standard or Dresden protocol was established in 2003 and treats the entire cornea. However, recent ultra-structural research showed that keratoconus is localized. Therefore, treating only the affected zone and minimalizing the risk of damaging surrounding tissues would be beneficial. The objective of this study is to evaluate whether the effectiveness of customized cross-linking (cCXL) is non-inferior to standard accelerated cross-linking (sCXL) in terms of flattening of the cornea and halting keratoconus progression.

Details

Lead sponsor	Maastricht University Medical Center
Phase	NA
Status	COMPLETED
Enrolment	124
Start date	Mon Mar 01 2021 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Wed Jun 05 2024 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

Keratoconus

Interventions

Customized crosslinking
Standard crosslinking

Countries

Netherlands