Epithelium-On Riboflavin — Competitive Intelligence Brief

Epithelium-On Riboflavin (Epithelium-On Riboflavin) competitive landscape: 3 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Corneal cross-linking agent. Area: Ophthalmology.

phase 3 Corneal cross-linking agent Corneal collagen (photochemical cross-linking via riboflavin and UVA) Ophthalmology Small molecule

Target snapshot

Epithelium-On Riboflavin (Epithelium-On Riboflavin) — Crowd Health Research, LTD. Epithelium-on riboflavin uses riboflavin (vitamin B2) with ultraviolet light exposure to strengthen corneal collagen cross-linking while preserving the corneal epithelium.

Comparator set (3 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Epithelium-On Riboflavin TARGET	Epithelium-On Riboflavin	Crowd Health Research, LTD	phase 3	Corneal cross-linking agent	Corneal collagen (photochemical cross-linking via riboflavin and UVA)
Epi-Off	Epi-Off	Icahn School of Medicine at Mount Sinai	phase 3	Corneal cross-linking agent	Corneal collagen (riboflavin-mediated photochemical cross-linking)
Epithelium-Off Riboflavin	Epithelium-Off Riboflavin	Crowd Health Research, LTD	phase 3	Corneal cross-linking agent	Corneal collagen (indirect via riboflavin photosensitization)
Riboflavin/Dextran	Riboflavin/Dextran	Cornea and Laser Eye Institute	phase 3	Corneal cross-linking agent	Corneal collagen (indirect via photochemical cross-linking)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Corneal cross-linking agent class)

1. Crowd Health Research, LTD · 2 drugs in this class
2. Cornea and Laser Eye Institute · 1 drug in this class
3. Icahn School of Medicine at Mount Sinai · 1 drug in this class