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dyclonine hydrochloride only
dyclonine hydrochloride only is a Local anesthetic Small molecule drug developed by Peking Union Medical College Hospital. It is currently FDA-approved for Topical anesthesia of mucous membranes, Local anesthesia for minor procedures.
Dyclonine hydrochloride is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.
Dyclonine hydrochloride is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Topical anesthesia of mucous membranes, Local anesthesia for minor procedures.
At a glance
| Generic name | dyclonine hydrochloride only |
|---|---|
| Sponsor | Peking Union Medical College Hospital |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
As a local anesthetic agent, dyclonine works by inhibiting sodium influx through voltage-gated sodium channels in neuronal membranes, which stabilizes the membrane and prevents depolarization. This action suppresses the generation and propagation of action potentials in sensory nerves, resulting in local anesthesia. It is typically used topically for surface anesthesia of mucous membranes.
Approved indications
- Topical anesthesia of mucous membranes
- Local anesthesia for minor procedures
Common side effects
- Local irritation or burning at application site
- Allergic contact dermatitis
- Systemic toxicity (rare, with excessive absorption)
Key clinical trials
- Oral Ondansetron to Improve Patient Experience of Unsedated Esophagogastroduodenoscopy Pilot Study (PHASE4)
- Ondansetron Combined with Dyclonine Hydrochloride to Improve Patient Experience in Unsedated Esophagogastro-duodenoscopy (PHASE4)
- Premedication Dyclonine Improves Visibility During Bowel Cleansing for Colonoscopy (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- dyclonine hydrochloride only CI brief — competitive landscape report
- dyclonine hydrochloride only updates RSS · CI watch RSS
- Peking Union Medical College Hospital portfolio CI
Frequently asked questions about dyclonine hydrochloride only
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Related
- Drug class: All Local anesthetic drugs
- Target: All drugs targeting Voltage-gated sodium channels
- Manufacturer: Peking Union Medical College Hospital — full pipeline
- Therapeutic area: All drugs in Anesthesia
- Indication: Drugs for Topical anesthesia of mucous membranes
- Indication: Drugs for Local anesthesia for minor procedures
- Compare: dyclonine hydrochloride only vs similar drugs
- Pricing: dyclonine hydrochloride only cost, discount & access