{"id":"dyclonine-hydrochloride-only","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or burning at application site"},{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Systemic toxicity (rare, with excessive absorption)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As a local anesthetic agent, dyclonine works by inhibiting sodium influx through voltage-gated sodium channels in neuronal membranes, which stabilizes the membrane and prevents depolarization. This action suppresses the generation and propagation of action potentials in sensory nerves, resulting in local anesthesia. It is typically used topically for surface anesthesia of mucous membranes.","oneSentence":"Dyclonine hydrochloride is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:32:32.664Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical anesthesia of mucous membranes"},{"name":"Local anesthesia for minor procedures"}]},"trialDetails":[{"nctId":"NCT07264738","phase":"PHASE4","title":"Oral Ondansetron to Improve Patient Experience of Unsedated Esophagogastroduodenoscopy Pilot Study","status":"ACTIVE_NOT_RECRUITING","sponsor":"Peking Union Medical College Hospital","startDate":"2025-07-01","conditions":"Esophagogastroduodensocopy (EGD) Procedure","enrollment":40},{"nctId":"NCT06729307","phase":"PHASE4","title":"Ondansetron Combined with Dyclonine Hydrochloride to Improve Patient Experience in Unsedated Esophagogastro-duodenoscopy","status":"NOT_YET_RECRUITING","sponsor":"Peking Union Medical College Hospital","startDate":"2025-01","conditions":"Esophagogastroduodensocopy (EGD) Procedure","enrollment":260},{"nctId":"NCT03352700","phase":"PHASE4","title":"Premedication Dyclonine Improves Visibility During Bowel Cleansing for Colonoscopy","status":"UNKNOWN","sponsor":"Changhai Hospital","startDate":"2017-12-01","conditions":"Bowel Preparation Scale, the Amount of Air Bubble, Adenoma Detection Rate","enrollment":580}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"dyclonine hydrochloride only","genericName":"dyclonine hydrochloride only","companyName":"Peking Union Medical College Hospital","companyId":"peking-union-medical-college-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dyclonine hydrochloride is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Topical anesthesia of mucous membranes, Local anesthesia for minor procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}