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Chloroprocaine 3% eye gel

Sintetica SA · Phase 3 active Small molecule

Chloroprocaine 3% eye gel is a Local anesthetic (ester) Small molecule drug developed by Sintetica SA. It is currently in Phase 3 development for Topical anesthesia of the eye for diagnostic procedures and minor ocular surgery. Also known as: Chemical Abstracts Service (CAS) nr 3858-89-7.

Chloroprocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses in the eye.

Chloroprocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses in the eye. Used for Topical anesthesia of the eye for diagnostic procedures and minor ocular surgery.

At a glance

Generic nameChloroprocaine 3% eye gel
Also known asChemical Abstracts Service (CAS) nr 3858-89-7
SponsorSintetica SA
Drug classLocal anesthetic (ester)
TargetVoltage-gated sodium channels
ModalitySmall molecule
Therapeutic areaOphthalmology
PhasePhase 3

Mechanism of action

As an ester-type local anesthetic, chloroprocaine reversibly inhibits sodium influx through voltage-gated sodium channels in sensory nerve fibers, thereby preventing depolarization and action potential propagation. When formulated as a 3% eye gel, it provides topical anesthesia to the ocular surface, numbing the cornea and conjunctiva for diagnostic or minor surgical procedures. The gel formulation allows prolonged contact and sustained anesthetic effect compared to solutions.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about Chloroprocaine 3% eye gel

What is Chloroprocaine 3% eye gel?

Chloroprocaine 3% eye gel is a Local anesthetic (ester) drug developed by Sintetica SA, indicated for Topical anesthesia of the eye for diagnostic procedures and minor ocular surgery.

How does Chloroprocaine 3% eye gel work?

Chloroprocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses in the eye.

What is Chloroprocaine 3% eye gel used for?

Chloroprocaine 3% eye gel is indicated for Topical anesthesia of the eye for diagnostic procedures and minor ocular surgery.

Who makes Chloroprocaine 3% eye gel?

Chloroprocaine 3% eye gel is developed by Sintetica SA (see full Sintetica SA pipeline at /company/sintetica-sa).

Is Chloroprocaine 3% eye gel also known as anything else?

Chloroprocaine 3% eye gel is also known as Chemical Abstracts Service (CAS) nr 3858-89-7.

What drug class is Chloroprocaine 3% eye gel in?

Chloroprocaine 3% eye gel belongs to the Local anesthetic (ester) class. See all Local anesthetic (ester) drugs at /class/local-anesthetic-ester.

What development phase is Chloroprocaine 3% eye gel in?

Chloroprocaine 3% eye gel is in Phase 3.

What are the side effects of Chloroprocaine 3% eye gel?

Common side effects of Chloroprocaine 3% eye gel include Corneal irritation or abrasion, Transient stinging or burning, Conjunctival erythema, Allergic reaction (rare).

What does Chloroprocaine 3% eye gel target?

Chloroprocaine 3% eye gel targets Voltage-gated sodium channels and is a Local anesthetic (ester).

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