{"id":"chloroprocaine-3-eye-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Corneal irritation or abrasion"},{"rate":null,"effect":"Transient stinging or burning"},{"rate":null,"effect":"Conjunctival erythema"},{"rate":null,"effect":"Allergic reaction (rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As an ester-type local anesthetic, chloroprocaine reversibly inhibits sodium influx through voltage-gated sodium channels in sensory nerve fibers, thereby preventing depolarization and action potential propagation. When formulated as a 3% eye gel, it provides topical anesthesia to the ocular surface, numbing the cornea and conjunctiva for diagnostic or minor surgical procedures. The gel formulation allows prolonged contact and sustained anesthetic effect compared to solutions.","oneSentence":"Chloroprocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses in the eye.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:05:44.204Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical anesthesia of the eye for diagnostic procedures and minor ocular surgery"}]},"trialDetails":[{"nctId":"NCT05926258","phase":"PHASE3","title":"Efficacy and Safety of Chloroprocaine 3% Gel and Oxybuprocaine 0.4% Eye Drops Anesthesia in Pediatric Population","status":"COMPLETED","sponsor":"Sintetica SA","startDate":"2024-05-23","conditions":"Local Anesthetic","enrollment":74},{"nctId":"NCT07456826","phase":"PHASE4","title":"Study Evaluating the Efficacy and Safety of Chloroprocaine HCl Ophthalmic Gel 3% vs Proparacaine Ophthalmic Solution 0.5% Plus Subconjunctival Lidocaine in Patients Undergoing Intravitreal Injections","status":"NOT_YET_RECRUITING","sponsor":"Harrow Inc","startDate":"2026-04","conditions":"Diabetic Macular Edema (DME), Age-Related Macular Degeneration (AMD), Retinal Vein Occlusion","enrollment":236},{"nctId":"NCT05934253","phase":"PHASE4","title":"The Effects of Low Viscosity Chloroprocaine Ophthalmic Gel 3% on the Bactericidal Action of Povidone-Iodine","status":"COMPLETED","sponsor":"Harrow Inc","startDate":"2023-07-15","conditions":"Antiseptic, Anesthesia, Local","enrollment":100},{"nctId":"NCT04685538","phase":"PHASE3","title":"Chloroprocaine 3% Gel Eye Drop as Topical Anestheticsin Phacoemulsification.","status":"COMPLETED","sponsor":"Sintetica SA","startDate":"2020-09-09","conditions":"Cataract","enrollment":338},{"nctId":"NCT04753710","phase":"PHASE2, PHASE3","title":"Efficacy, Safety and Tolerability Study of Chloroprocaine 3% Gel Eye Drops in Healthy Volunteers","status":"COMPLETED","sponsor":"Sintetica SA","startDate":"2020-06-29","conditions":"Healthy Volunteers","enrollment":96},{"nctId":"NCT04779606","phase":"PHASE1, PHASE2","title":"Efficacy, Safety and Local Tolerability Study of Chloroprocaine 3% Gel Eye Drops in Healthy Volunteers","status":"COMPLETED","sponsor":"Sintetica SA","startDate":"2020-06-16","conditions":"Healthy Subjects","enrollment":105}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Chemical Abstracts Service (CAS) nr 3858-89-7"],"phase":"phase_3","status":"active","brandName":"Chloroprocaine 3% eye gel","genericName":"Chloroprocaine 3% eye gel","companyName":"Sintetica SA","companyId":"sintetica-sa","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chloroprocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses in the eye. Used for Topical anesthesia of the eye for diagnostic procedures and minor ocular surgery.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}