Discontinued drugs — immunology
Drug development has roughly a 90% failure rate. This tracker catalogues compounds that were halted in clinical development or withdrawn after marketing, with the documented reason and the sponsor. Useful for understanding what's worked vs. what hasn't in a given disease, mechanism, or class.
- Rimatil · Immunology · bucillamine
Bucillamine works by binding to copper ions in the body, reducing inflammation and oxidative stress. - Sasapyrine · Immunology · salsalate
Salsalate works by inhibiting the enzyme COX-1 and COX-2, which are responsible for producing prostaglandins. - Trilisate · Immunology · choline magnesium trisalicylate
Trilisate works by blocking the production of prostaglandins, hormone-like substances that cause pain and inflammation. - VILOBELIMAB · Immunology
12.1 Mechanism of Action GOHIBIC is a chimeric monoclonal IgG4-kappa antibody that binds to C5a with a dissociation constant of 9.6pM and blocks its interaction with the C5a receptor. C5a is part of the complement system and is activated as part of the innate immune response initiating an inflammatory cascade that includes increased vascular permeability, coagulation, proinflammatory cytokine release, and recruitment and activation of neutrophils and other myeloid cells. - ocrelizumabu 200mg · Chugai Pharmaceutical · Immunology · B-cell depleting monoclonal antibody; immunosuppressant
Ocrelizumab selectively depletes CD20+ B lymphocytes to suppress autoimmune-mediated inflammation. - Aselend · Fujimoto Pharmaceutical Corporation · Immunology · sodium selenite
Aselend works by providing the body with selenium, an essential mineral that plays a crucial role in various bodily functions. - ODSH at 0.125 mg/kg/h · Jazz Pharmaceuticals · Immunology · Protein sequestrant; modified polysaccharide; orphan therapeutic
ODSH is a modified chitosan polymer that binds intestinal lymphatic proteins to reduce protein loss in enteropathy. - Vioxx · M.D. Anderson Cancer Center · Immunology
- Crixivan · Merck & Co. · Immunology · indinavir
Crixivan blocks the replication of HIV by inhibiting the protease enzyme, which is essential for the virus to produce new particles. - Raptiva · National Institute of Dental and Craniofacial Research (NIDCR) · Immunology
- Paxlovid (Copackaged) · Pfizer · Immunology
Paxlovid works by inhibiting the activity of the SARS-CoV-2 protease enzyme, which is essential for the virus's replication. - Tasocitinib · Pfizer · Immunology
- PF-07038124 · Pfizer Inc. · Immunology · Phosphodiesterase-4 inhibitor
PF-07038124 is a topical PDE4 inhibitor that blocks phosphodiesterase-4 to reduce inflammatory cytokine production in skin immune cells. - immunosuppression · Prof. Dr. med. Wolfgang Bethge · Immunology
- Hydroxychloroquine Sulfate · Sanofi · Immunology · Antimalarial
Hydroxychloroquine Sulfate works by interfering with the replication of malaria parasites and modulating the immune system to treat autoimmune diseases. - Emapalumab-Lzsg · Swedish Orphan Biovitrum · Immunology · Interferon gamma Blocker [EPC]
12.1 Mechanism of Action Emapalumab-lzsg is a monoclonal antibody that binds to and neutralizes interferon gamma (IFNγ). Nonclinical data suggest that IFNγ plays a pivotal role in the pathogenesis of HLH by being hypersecreted. - Nerventra · Teva · Immunology · laquinimod
Nerventra works by modulating the immune system to reduce inflammation in the central nervous system. - Amevive · University Hospitals Cleveland Medical Center · Immunology