Merck & Co. (MRK)

Quick facts

Marketed products

• Keytruda · Oncology · revenue 29500
  Pembrolizumab blocks PD-1 receptor, releasing immune inhibition and enhancing anti-tumor T-cell response.
• Winrevair · Cardiovascular · revenue 1443
  Winrevair works by binding to and inhibiting the activity of activin receptors, which play a role in the development of pulmonary arterial hypertension.
• Prevymis · Infectious Disease · revenue 978
  Prevymis works by inhibiting the DNA terminase complex of the cytomegalovirus, preventing the virus from replicating.
• Elspar · Oncology · revenue 600
  RYLAZE kills leukemic cells by depleting plasma asparagine, which they need for survival.
• Welireg · Oncology · revenue 509
  Belzutifan inhibits HIF-2α, blocking its interaction with HIF-1β to reduce expression of genes linked to tumor growth.
• Bavencio · Oncology · revenue 400
  Bavencio blocks the PD-L1 protein, allowing the immune system to recognize and attack cancer cells.
• Tindal · Other
• Adefovir dipivoxil (adefovir) · Virology / Infectious Disease
  Adefovir dipivoxil is a nucleotide reverse transcriptase inhibitor that blocks viral DNA polymerase activity in hepatitis B virus.
• Fosamax · Bone
  Fosamax works by inhibiting bone resorption, allowing bone density to increase.
• Aminohippurate · Hematology
• Andion · Hematology
  Andion works by inhibiting Vitamin K-dependent gamma-carboxylase, an enzyme necessary for blood clotting.
• Antiemetic · Other
• Antihyperglycemic Medication · Diabetes
  This drug reduces blood glucose by inhibiting the sodium-glucose cotransporter 2 (SGLT2) in the kidney, allowing excess glucose to be excreted in urine.
• Emend · Oncology
  Emend works by blocking the action of a natural substance called substance P, which is involved in the vomiting reflex.
• AzaSite® · Ophthalmology
  AzaSite is an azithromycin ophthalmic suspension that reduces bacterial load and inflammatory mediators in the eye to treat bacterial conjunctivitis and meibomian gland dysfunction.
• AzaSite Eye Drops · Ophthalmology
  AzaSite is an azithromycin ophthalmic suspension that reduces bacterial load and inflammatory mediators in the eye to treat bacterial conjunctivitis and meibomian gland dysfunction.
• Azithromycin Ophthalmic Solution, 1% · Ophthalmology / Infectious Disease
  Azithromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby killing or stopping the growth of susceptible bacteria.
• KEYTRUDA QLEX · Other
• Diprolene · Oncology
  Diprolene works by binding to the glucocorticoid receptor in the skin, which reduces inflammation and suppresses the immune system.
• Celestone Soluspan · Immunology
• Zinplava · Infectious Disease
  Zinplava works by binding to and neutralizing toxins produced by Clostridium difficile bacteria.
• Victrelis · Infectious Disease
• Calcitriol Cream
• Calogen® · Nutrition/Supportive Care
  Calogen is a high-calorie, high-fat oral nutritional supplement that provides concentrated energy to support weight maintenance and nutritional status in patients with increased caloric requirements.
• Cancidas · Infectious Disease
  Cancidas works by inhibiting the synthesis of beta-1,6-glucan, a critical component of the fungal cell wall.
• Cetrotide · Other
• Ovidrel · Immunology
• Primaxin · Metabolic
  Primaxin works by inhibiting the action of dehydropeptidase, an enzyme that breaks down certain antibiotics, thereby protecting them from degradation and allowing them to reach effective concentrations in the body.
• Comparator: ceftriaxone + metronidazole · Infectious Disease
  This is a fixed-dose combination of two antibiotics: ceftriaxone (a third-generation cephalosporin) inhibits bacterial cell wall synthesis, while metronidazole is a nitroimidazole that disrupts anaerobic bacterial DNA.
• Comparator: glimepiride · Diabetes
  Glimepiride stimulates insulin secretion from pancreatic beta cells by binding to sulfonylurea receptors on the cell membrane.
• Comparator: Infanrix™ · Immunology / Infectious Disease
  Infanrix is a combination vaccine that stimulates the immune system to produce antibodies against diphtheria, tetanus, and pertussis (whooping cough) pathogens.
• Comparator: PedvaxHIB™ · Immunology / Infectious Disease
  PedvaxHIB is a conjugate vaccine that stimulates the immune system to produce antibodies against Haemophilus influenzae type b (Hib) by presenting the bacterial polysaccharide capsule linked to a protein carrier.
• Comparator: Sulfonylurea · Diabetes
  Sulfonylureas stimulate insulin secretion from pancreatic beta cells by blocking ATP-sensitive potassium channels.
• Comparator: VAQTA™ · Immunology / Infectious Disease
  VAQTA is an inactivated hepatitis A vaccine that stimulates the immune system to produce antibodies against hepatitis A virus.
• Org 36286 · Other
• Immune Support · Immunology
• DAPTACEL™ · Immunology
• Ortho-Cept · Other
• Sincortex · Other
• Decadron-La · Oncology

Phase 3 pipeline

• Acetaminophen (or equivalent) · Pain Management
  Acetaminophen reduces pain and fever by inhibiting prostaglandin synthesis in the central nervous system.
• Amoxicillin/clavulunate potassium · Infectious Disease
  Amoxicillin/clavulanate is a beta-lactam antibiotic combination that kills bacteria by inhibiting cell wall synthesis, with clavulanate protecting amoxicillin from degradation by bacterial beta-lactamases.
• Background PAH Therapy · Cardiovascular
  Background PAH Therapy refers to foundational pulmonary arterial hypertension treatment, typically involving vasodilators and/or endothelin receptor antagonists to reduce pulmonary vascular resistance.
• Boceprevir (BOC) · Virology/Hepatology
  Boceprevir is a hepatitis C virus (HCV) NS3 protease inhibitor that blocks viral protein processing and replication.
• boceprevir (SCH 503034)
• Calderasib · Other
• Cisplatin (as radiosensitizer) · Oncology
  Cisplatin acts as a radiosensitizer by forming DNA adducts that enhance the cytotoxic effects of ionizing radiation, making cancer cells more susceptible to radiation-induced damage.
• Colistimethate sodium (CMS) · Infectious Disease
  Colistimethate sodium is a prodrug that is hydrolyzed to colistin, which disrupts bacterial cell membranes by binding to lipopolysaccharides and causing cell lysis.
• Comparator: Adacel™ · Immunology / Infectious Disease
  Adacel is a combination vaccine that stimulates the immune system to produce antibodies against diphtheria, tetanus, pertussis (whooping cough), and poliomyelitis.
• Comparator: Antidiabetic Standard of Care · Diabetes
  This is a comparator arm representing standard-of-care antidiabetic therapy used as a control reference in clinical trials, not a specific drug with a single mechanism.
• Comparator: Aprepitant · Oncology
  Aprepitant is a neurokinin-1 (NK1) receptor antagonist that blocks substance P signaling in the chemoreceptor trigger zone and vomiting center to prevent nausea and vomiting.
• Comparator: cefotetan · Infectious Disease
  Cefotetan is a second-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins.
• Comparator: ceftriaxone sodium · Infectious Disease
  Ceftriaxone sodium is a third-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins.
• Comparator: Comparator: ENGERIX-B · Immunology / Infectious Disease
  ENGERIX-B is a hepatitis B vaccine that stimulates the immune system to produce antibodies against hepatitis B surface antigen (HBsAg).
• Comparator: Comvax · Immunology / Infectious Disease
  Comvax is a combination vaccine that provides immunization against hepatitis B virus and Haemophilus influenzae type b (Hib) by stimulating the immune system to produce protective antibodies against both pathogens.
• Comparator: dexamethasone · Immunology, Rheumatology, Oncology (supportive care)
  Dexamethasone is a synthetic glucocorticoid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors.
• Comparator: dorzolamide hydrochloride · Ophthalmology
  Dorzolamide hydrochloride inhibits carbonic anhydrase II in the eye, reducing aqueous humor production and lowering intraocular pressure.
• Comparator: efavirenz · Infectious Disease / Virology
  Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that blocks HIV reverse transcriptase to prevent viral replication.
• Comparator: ENGERIX-B™ · Immunology / Infectious Disease
  ENGERIX-B is a recombinant hepatitis B vaccine that stimulates the immune system to produce antibodies against hepatitis B surface antigen (HBsAg), providing protection against hepatitis B virus infection.
• Comparator: fluticasone · Respiratory / Pulmonology
  Fluticasone is a corticosteroid that reduces inflammation by binding to glucocorticoid receptors and suppressing immune cell activation and inflammatory mediator release.
• Comparator: fosaprepitant dimeglumine · Oncology
  Fosaprepitant dimeglumine is a neurokinin-1 (NK1) receptor antagonist that blocks substance P signaling in the chemoreceptor trigger zone and vomiting center to prevent chemotherapy-induced nausea and vomiting.
• Comparator: Gardasil · Oncology / Immunology / Infectious Disease
  Gardasil is a recombinant quadrivalent human papillomavirus (HPV) vaccine that stimulates the immune system to produce antibodies against HPV types 6, 11, 16, and 18.
• Comparator: glipizide · Diabetes
  Glipizide stimulates insulin secretion from pancreatic beta cells by blocking ATP-sensitive potassium channels.
• Comparator: Infanrix(tm) Hexa · Immunology / Infectious Disease Prevention
  Infanrix Hexa is a combination vaccine that stimulates the immune system to produce antibodies against six infectious diseases by presenting inactivated or toxoid antigens.
• Comparator: Influenza Vaccine · Immunology
  Influenza vaccine stimulates the immune system to produce antibodies and cellular immunity against influenza virus strains, providing protection against infection.
• Comparator: Losartan · Cardiovascular
  Losartan blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction and aldosterone release to lower blood pressure.
• Comparator: M-M-R II · Immunology / Infectious Disease
  M-M-R II is a live attenuated viral vaccine that stimulates immune response against measles, mumps, and rubella by introducing weakened forms of these viruses.
• Comparator: Micafungin sodium · Infectious Disease
  Micafungin sodium inhibits fungal cell wall synthesis by targeting 1,3-beta-D-glucan synthase, leading to fungal cell death.
• Comparator: MK0517 · Oncology; Gastroenterology
  MK0517 is a selective antagonist of the neurokinin-1 (NK1) receptor that blocks substance P signaling in the central nervous system.
• Comparator: Modified Process Vaccine · Immunology
  A modified process vaccine that stimulates the immune system to recognize and respond to specific disease antigens through an altered manufacturing or formulation approach.
• Comparator: niacin · Cardiovascular
  Niacin (vitamin B3) raises HDL cholesterol and lowers triglycerides and LDL cholesterol by inhibiting hepatic VLDL production and increasing apolipoprotein A-I.
• Comparator: niacin + laropiprant · Cardiovascular
  Niacin raises HDL cholesterol and lowers triglycerides, while laropiprant blocks the prostaglandin D2 receptor to reduce niacin-induced flushing.
• Comparator: ondansetron IV · Supportive Care / Antiemetic
  Ondansetron is a selective 5-HT3 receptor antagonist that blocks serotonin signaling in the chemoreceptor trigger zone and gastrointestinal tract to prevent nausea and vomiting.
• Comparator: oxycodone and acetaminophen · Pain Management
  This is a fixed-dose combination of oxycodone (a mu-opioid receptor agonist) and acetaminophen (a non-opioid analgesic) that provides pain relief through dual mechanisms.
• Comparator: paroxetine HCL · Psychiatry / Neurology
  Paroxetine HCl selectively inhibits the reuptake of serotonin at the neuronal synapse, increasing serotonin availability in the brain.
• Comparator: Placebo matching RotaTeq™ · Immunology/Infectious Disease
  This is a placebo comparator arm in a RotaTeq clinical trial, not an active drug.
• Comparator: placebo metformin · Diabetes
  Metformin reduces hepatic glucose production and improves insulin sensitivity in peripheral tissues.
• Comparator: Placebo to aprepitant · Oncology
  Aprepitant is a neurokinin-1 (NK1) receptor antagonist that blocks substance P signaling in the chemoreceptor trigger zone and vomiting center to prevent chemotherapy-induced nausea and vomiting.
• Comparator: Placebo to efavirenz · Infectious Disease / Virology
  Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that blocks HIV reverse transcriptase to prevent viral replication.
• Comparator: Placebo to MK-0518 · Infectious Disease
  MK-0518 is an integrase strand transfer inhibitor that blocks HIV integrase, preventing the virus from inserting its genetic material into human DNA.

Competitive intelligence

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Related

• Keytruda · Oncology
• Winrevair · Cardiovascular
• Prevymis · Infectious Disease
• Elspar · Oncology
• Welireg · Oncology
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