Last reviewed 2026-04-20 · How we verify

Sincortex (DESOXYCORTICOSTERONE ACETATE)

Merck & Co. · FDA-approved approved Small molecule Quality 15/100

Sincortex (generic name: DESOXYCORTICOSTERONE ACETATE) is a desoxycorticosterone acetate Small molecule drug developed by Merck & Co.. It is currently FDA-approved (first approved 1939).

Desoxycorticosterone acetate (Sincortex), marketed by Merck & Co., is a mineralocorticoid receptor agonist used primarily in conditions requiring mineralocorticoid replacement therapy. Its key strength lies in its mechanism of action, which closely mimics natural hormone effects, providing a targeted therapeutic approach. The primary risk is the upcoming key composition patent expiry in 2028, which could lead to increased competition from generics.

At a glance

Generic name	DESOXYCORTICOSTERONE ACETATE
Sponsor	Merck & Co.
Drug class	desoxycorticosterone acetate
Target	Mineralocorticoid receptor
Modality	Small molecule
Therapeutic area	Other
Phase	FDA-approved
First approval	1939

Approved indications

No approved indications tracked.

Common side effects

No common side effects on file.

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Source	Used for
FDA label	Mechanism, indications, dosing, boxed warnings, drug interactions

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

Sincortex CI brief — competitive landscape report
Sincortex updates RSS · CI watch RSS
Merck & Co. portfolio CI

Frequently asked questions about Sincortex

What is Sincortex?

Sincortex (DESOXYCORTICOSTERONE ACETATE) is a desoxycorticosterone acetate drug developed by Merck & Co..

Who makes Sincortex?

Sincortex is developed and marketed by Merck & Co. (see full Merck & Co. pipeline at /company/merck).

What is the generic name of Sincortex?

DESOXYCORTICOSTERONE ACETATE is the generic (nonproprietary) name of Sincortex.

What drug class is Sincortex in?

Sincortex belongs to the desoxycorticosterone acetate class. See all desoxycorticosterone acetate drugs at /class/desoxycorticosterone-acetate.

When was Sincortex approved?

Sincortex was first approved on 1939.

What development phase is Sincortex in?

Sincortex is FDA-approved (marketed).

What does Sincortex target?

Sincortex targets Mineralocorticoid receptor and is a desoxycorticosterone acetate.

Drug class: All desoxycorticosterone acetate drugs
Target: All drugs targeting Mineralocorticoid receptor
Manufacturer: Merck & Co. — full pipeline
Therapeutic area: All drugs in Other

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing