Merck KGaA, Darmstadt, Germany

Quick facts

Marketed products

• Biltricide® · Infectious Disease / Parasitology
  Praziquantel causes muscular paralysis and death of parasitic worms by increasing cell membrane permeability to calcium ions.
• Colposeptine · Other
• Efalizumab (Raptiva) · Immunology/Dermatology
  Efalizumab is a monoclonal antibody that blocks CD11a on T cells, preventing their activation and migration to the skin.
• Gabapentin/B-complex · Neurology; Pain Management
  Gabapentin reduces neuronal excitability by binding to the alpha-2-delta subunit of voltage-gated calcium channels, while B-complex vitamins support neuronal metabolism and myelin formation.
• GnRH antagonist
• GONAL-f®
• GONAL f® prefilled pen
• Gonal -f® [r-hFSH]
• High Dose Bisoprolol · Cardiovascular
  High-dose bisoprolol is a selective beta-1 adrenergic receptor antagonist that reduces heart rate and cardiac contractility to lower blood pressure and improve cardiac function.
• Interferon beta-1a (Rebif) · Immunology / Neurology
  Interferon beta-1a activates interferon signaling pathways to modulate immune responses and reduce inflammatory activity in the central nervous system.
• Kuvan® · Metabolic/Genetic Disorders
  Kuvan is a synthetic form of tetrahydrofolate (BH4) that acts as a cofactor to restore phenylalanine ammonia-lyase (PAL) enzyme activity, enabling the metabolism of phenylalanine in patients with phenylketonuria.
• Low Dose Bisoprolol · Cardiovascular
  Bisoprolol is a beta-1 selective adrenergic receptor antagonist that reduces heart rate and blood pressure by blocking the effects of catecholamines on the heart.
• Luveris® · Reproductive endocrinology; Fertility
  Luveris is a recombinant human luteinizing hormone (LH) that stimulates ovarian steroid production and follicle development in women undergoing fertility treatment.
• Ovitrelle® [r-hCG alfa] · Reproductive Medicine / Fertility
  Ovitrelle is a recombinant human chorionic gonadotropin (r-hCG) that binds to luteinizing hormone (LH) receptors to trigger final oocyte maturation and ovulation.
• Pergoveris®
• r-hGH
• Rebif® (clone 484-39) · Immunology / Neurology
  Rebif is an interferon beta-1a that activates interferon receptors on immune cells to modulate immune response and reduce inflammation in the central nervous system.
• Sigmart (nicorandil) · Cardiovascular
  Nicorandil opens ATP-sensitive potassium channels in vascular smooth muscle and also has nitrate-like vasodilatory properties, reducing cardiac preload and afterload.
• Systemic corticosteroids/methotrexate · Immunology / Rheumatology
  This combination suppresses immune system activity through corticosteroid-mediated anti-inflammatory effects and methotrexate-induced immunosuppression via folate antagonism.

Phase 3 pipeline

• cetuximab + cisplatin + vinorelbine · Oncology
  Cetuximab targets the epidermal growth factor receptor (EGFR), while cisplatin and vinorelbine work by interfering with DNA replication and cell division.
• Cetuximab + concomitant boost radiotherapy · Oncology
  Cetuximab blocks epidermal growth factor receptor (EGFR) signaling to inhibit tumor cell growth, and when combined with concomitant boost radiotherapy, enhances radiation-induced cell death in cancer cells.
• cisplatin + vinorelbine · Oncology
  Cisplatin and vinorelbine work together as a chemotherapy combination to kill cancer cells by damaging DNA and disrupting microtubule formation.
• COL-1620 · Fibrosis / Respiratory
  COL-1620 is a selective inhibitor of collagen-producing fibroblasts that reduces excessive collagen deposition in fibrotic tissues.
• F0434 · Oncology
  F0434 is an investigational immunotherapy agent designed to modulate immune responses, likely through checkpoint inhibition or T-cell activation pathways.
• Follitropin alfa liquid formulation · Reproductive Medicine / Fertility
  Follitropin alfa is a recombinant human follicle-stimulating hormone (FSH) that stimulates ovarian follicle development and estrogen production in women.
• Follitropin beta liquid formulation · Reproductive Endocrinology / Fertility
  Follitropin beta is a recombinant human follicle-stimulating hormone (FSH) that stimulates the growth and maturation of ovarian follicles in women and spermatogenesis in men.
• Gonalef® (Follitropin alfa) · Reproductive/Fertility
  Follitropin alfa is a recombinant human follicle-stimulating hormone (FSH) that stimulates the growth and maturation of ovarian follicles in women.
• IR Prednisone · Immunology, Rheumatology, Endocrinology
  IR Prednisone is a corticosteroid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.
• Micronised Progesterone
• MSJ-0011 · Oncology
  MSJ-0011 is an investigational immunotherapy that modulates immune checkpoint pathways to enhance anti-tumor immune responses.
• Placebo and Saizen® · Endocrinology
  Saizen® is a recombinant human growth hormone that replaces or supplements endogenous growth hormone to promote growth and metabolic effects.
• Placebo - IR Prednisone
  This is a placebo control arm in a clinical trial; it contains no active pharmaceutical ingredient and produces no pharmacological effect.
• Placebo - MR Prednisone · Immunology/Rheumatology
  This is a placebo control, not an active drug, and therefore has no pharmacological mechanism of action.
• Rebif New Formulation + ibuprofen PRN · Immunology / Neurology
  Rebif (interferon beta-1a) activates interferon signaling pathways to modulate immune responses and reduce inflammation in the central nervous system.
• Rebif New Formulation + prophylactic Ibuprofen · Immunology / Neurology
  Rebif (interferon beta-1a) activates interferon signaling pathways to modulate immune responses and reduce inflammation in the central nervous system, while prophylactic ibuprofen mitigates injection-site reactions and systemic inflammatory side effects.
• RNF · Oncology
  RNF is a small molecule targeting the CD47/SIRPα axis.
• Saizen® A · Endocrinology
  Saizen A is a recombinant human growth hormone analogue used to treat growth hormone deficiency.
• Saizen® B · Endocrinology
  Saizen B is a recombinant human growth hormone used to treat growth hormone deficiency.
• Tecemotide (L-BLP25) · Oncology
  Tecemotide is a cancer vaccine that stimulates the immune system to recognize and attack cancer cells expressing MUC1 antigen.
• Urinary-hCG · Reproductive/Endocrinology
  Urinary-hCG is a human chorionic gonadotropin (hCG) derived from urine that stimulates hormone production in reproductive tissues.
• urinary hCG (u-hCG) · Gynecology
  Urinary hCG is a diagnostic test that detects the presence of human chorionic gonadotropin in urine.

Phase 2 pipeline

• Analogous GnRH antagonist · Oncology; Reproductive/Endocrinology
  This GnRH antagonist blocks gonadotropin-releasing hormone receptors to suppress luteinizing hormone and follicle-stimulating hormone, reducing sex hormone production.
• Cetrorelix acetate and Follitropin alfa · Oncology
  Cetrorelix acetate is a GnRH antagonist, and Follitropin alfa is a recombinant human FSH analogue.
• EMD 525797
• Levo Praziquantel ODT
• Long GnRH agonist
• MSB0011359C
• Multiple low dose cyclophosphamide
• Racemate Praziquantel ODT
• Rebif® New Formulation
• recombinant somatropin
• u-hCG

Phase 1 pipeline

• AS902330
• Bisoprolol-Amlodipine FDC
• Cesol®
• Cisticid · Other
• Cysticide · Infectious Disease
• EMD 521873
• EMD 640744
• EMD525797
• Freeze-dried pergoveris
• L-PZQ ODT
• Liquid pergoveris
• M5717
• M6495
• M7583
• MSB0010841
• MSC2156119J
• MSC2499550A
• ODT-PZQ
• Rac-PZQ ODT
• Reference GIR
• Reference GXR
• Tepotinib TF2
• Tepotinib TF3
• Test GIR
• Test GXR
• Unlabeled TH-302

Competitive intelligence

For the full portfolio CI brief — phase mix, recent regulatory actions, upcoming PDUFA dates, patent timeline, class-overlap with competitors:

• Merck KGaA, Darmstadt, Germany portfolio CI brief
• Merck KGaA, Darmstadt, Germany pipeline updates RSS

Frequently asked questions about Merck KGaA, Darmstadt, Germany

Related

• Biltricide® · Infectious Disease / Parasitology
• Colposeptine · Other
• Efalizumab (Raptiva) · Immunology/Dermatology
• Gabapentin/B-complex · Neurology; Pain Management
• GnRH antagonist
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